Document Detail

Radical modulation activity of pine cone extracts of Pinus elliottii var. Elliottii.
MedLine Citation:
PMID:  10226567     Owner:  NLM     Status:  MEDLINE    
The radical modulation activity of lignins prepared from the cone of Pinus elliottii var. Elliottii was investigated, using ESR spectroscopy. These lignins produced radical(s) under alkaline conditions, and the radical intensity was increased with increasing pH. Lower concentrations of lignins slightly reduced the radical intensity of sodium ascorbate, whereas higher concentrations of lignins enhanced both the radical intensity and cytotoxic activity of sodium ascorbate. Lignins effectively scavenged superoxide anion, produced by hypoxanthine-xanthine oxidase reaction. Elliottii lignins significantly inhibited the human immunodeficiency virus (HIV)-induced cytopathic effect, in similar fashions to other natural, commercial and synthetic lignins. Pretreatment of mice with lignins significantly protected them from the lethal infection with E. coli. Crude alkaline extracts of Elliottii pine cone displayed similar magnitude of activity with lignins. These data further supports the medicinal efficacy of plant extracts.
K Satoh; T Kihara; Y Ida; H Sakagami; N Koyama; M Premanathan; R Arakaki; H Nakashima; N Komatsu; M Fujimaki; Y Misawa; N Hata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  19     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM; X    
Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
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MeSH Terms
Anti-HIV Agents / pharmacology
Ascorbic Acid / pharmacology
Free Radicals
Lignin / pharmacology*
Plant Extracts / pharmacology
Plants, Medicinal*
Superoxides / metabolism
Reg. No./Substance:
0/Anti-HIV Agents; 0/Free Radicals; 0/Plant Extracts; 11062-77-4/Superoxides; 50-81-7/Ascorbic Acid; 9005-53-2/Lignin

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