Document Detail

Radiation therapy for early glottic carcinoma (T1N0M0). The adverse effect of treatment interruption.
MedLine Citation:
PMID:  9353428     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Clarification of the adverse effects of treatment interruption on the local control of early glottic carcinoma. PATIENTS AND METHODS: From May 1982 through February 1992, 273 patients with early glottic carcinoma (T1N0M0) were treated at this department. Of 253 patients administered 60 Gy in 30 fractions 77 patients had no treatment interruption and treatment was completed within 6 weeks (group I), overall treatment time was prolonged for 176 patients: 141 patients 43 to 49 days (group II) and 35 patients 50 to 62 days (group III). Treatment was interrupted due to public holidays (156 cases), patients convenience (13 cases) and severe mucosal reactions (seven cases). The major reason was public holidays, 91% in group II and 80% in group III. RESULTS: The 3-year recurrence-free survival rates were for group I 95%, group II 89% and group II 80%. Survivals for groups I and II, groups II and III and groups I and III were essentially the same. At 40 Gy tumor clearance was more than 50% in the 3-groups. For complete clearance cases at 40 Gy, recurrence-free survival was essentially the same for the 3 groups although for incomplete clearance cases, statistically significant difference for groups I and III (log-rank test p = 0.0004; Wilcoxon test p = 0.0004) and marginally significant difference for groups II and III (p = 0.0157, p = 0.0045) but no difference for groups I and II (p = 0.0669, p = 0.0853) were noted by adjusting the p-value. CONCLUSION: Prolongation of overall treatment time and tumor clearance at 40 Gy appeared to be a factor of the local control.
M Chatani; Y Matayoshi; N Masaki; T Teshima; T Inoue
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]     Volume:  173     ISSN:  0179-7158     ISO Abbreviation:  Strahlenther Onkol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-21     Completed Date:  1997-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8603469     Medline TA:  Strahlenther Onkol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  502-6     Citation Subset:  IM    
Department of Radiation Therapy, Osaka Medical Center for Cancer and Cardiovascular Disease, Japan.
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MeSH Terms
Carcinoma / mortality,  radiotherapy*
Data Interpretation, Statistical
Disease-Free Survival
Laryngeal Neoplasms / mortality,  radiotherapy*
Middle Aged
Neoplasm Recurrence, Local
Radiotherapy Dosage
Retrospective Studies
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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