Document Detail


Radiation response of E. coli after combined treatment with misonidazole and WR-2721 at various oxygen concentrations.
MedLine Citation:
PMID:  2177609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported that the aminothiol compound WR-2721 is a promising radioprotective agent and in combination with misonidazole (MISO) seems to be of therapeutic benefit. Since the radiomodification is oxygen-dependent, the actual oxygen status of cells and the surrounding media is an important factor influencing their effectiveness. Escherichia coli B/r radioresponse was studied either alone or in combination with these compounds at various oxygen concentrations ranging from anoxia to high oxygen content. WR-2721 had a protective effect under anoxic conditions and gave overall protection when oxygen was present. The maximum protection was seen at 3.2% O2 in N2 (PF 2.08). In combination with MISO the hypoxic sensitization of MISO was completely abolished by WR-2721, resulting in radioprotection under hypoxic conditions as well. Under euoxic conditions MISO was able to reduce the protective effect of WR-2721 by about 21%. According to our results MISO and WR-2721 influence each other in their radiomodifying effect in either fixation or repair of the radiation-induced damage.
Authors:
A M Dám; L G Gazsó; K Bodó
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  29     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-14     Completed Date:  1991-03-14     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  1055-8     Citation Subset:  IM    
Affiliation:
Frederic Joliot-Curie National Research Institute for Radiobiology and Radio-Hygiene, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Amifostine / metabolism,  pharmacology*
Escherichia coli / metabolism,  radiation effects*
Misonidazole / pharmacology*
Oxidation-Reduction
Oxygen / metabolism*
Radiation Tolerance / drug effects*
Radiobiology
Chemical
Reg. No./Substance:
13551-87-6/Misonidazole; 20537-88-6/Amifostine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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