| Radiation response of E. coli after combined treatment with misonidazole and WR-2721 at various oxygen concentrations. | |
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MedLine Citation:
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PMID: 2177609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that the aminothiol compound WR-2721 is a promising radioprotective agent and in combination with misonidazole (MISO) seems to be of therapeutic benefit. Since the radiomodification is oxygen-dependent, the actual oxygen status of cells and the surrounding media is an important factor influencing their effectiveness. Escherichia coli B/r radioresponse was studied either alone or in combination with these compounds at various oxygen concentrations ranging from anoxia to high oxygen content. WR-2721 had a protective effect under anoxic conditions and gave overall protection when oxygen was present. The maximum protection was seen at 3.2% O2 in N2 (PF 2.08). In combination with MISO the hypoxic sensitization of MISO was completely abolished by WR-2721, resulting in radioprotection under hypoxic conditions as well. Under euoxic conditions MISO was able to reduce the protective effect of WR-2721 by about 21%. According to our results MISO and WR-2721 influence each other in their radiomodifying effect in either fixation or repair of the radiation-induced damage. |
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Authors:
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A M Dám; L G Gazsó; K Bodó |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oncologica (Stockholm, Sweden) Volume: 29 ISSN: 0284-186X ISO Abbreviation: Acta Oncol Publication Date: 1990 |
Date Detail:
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Created Date: 1991-03-14 Completed Date: 1991-03-14 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 1055-8 Citation Subset: IM |
Affiliation:
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Frederic Joliot-Curie National Research Institute for Radiobiology and Radio-Hygiene, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amifostine
/
metabolism,
pharmacology* Escherichia coli / metabolism, radiation effects* Misonidazole / pharmacology* Oxidation-Reduction Oxygen / metabolism* Radiation Tolerance / drug effects* Radiobiology |
| Chemical | |
Reg. No./Substance:
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13551-87-6/Misonidazole; 20537-88-6/Amifostine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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