Document Detail

Radiation-induced valvular disease is the logical consequence of irradiation.
MedLine Citation:
PMID:  17444176     Owner:  NLM     Status:  MEDLINE    
Mediastinal irradiation has been reported to induce cardiac diseases such as pericardial disease, accelerated arteriosclerosis of the coronary arteries, valvular disease, conduction abnormalities, and calcification of the aorta. We experienced four cases of radiation-induced valvular disease. All patients had histories of radiation therapy and had aortic valve disease. All patients had marked fibrosis of the mediastinum and hypertrophy of pericardium. The aortic valve leaflets were tricuspid and fibrotic with focal dystrophic calcification and markedly thickened. In the pathological findings, certain rheumatic endocarditis changes such as endocardial reduplication and vascularization were not found in all aortic valves. The mechanism of radiation-induced cardiac disease is not clear. However, those changes seem to progress very slowly. Thus, long-term follow-up care is particularly important for patients undergoing radiation therapy. Fortunately, today's irradiation techniques are much less harmful; therefore, radiation-induced cardiac disease will likely become more rare in the future.
Atsushi Tamura; Yoshiharu Takahara; Kenji Mogi; Masayoshi Katsumata
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  General thoracic and cardiovascular surgery     Volume:  55     ISSN:  1863-6705     ISO Abbreviation:  -     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-08-17     Revised Date:  2007-10-30    
Medline Journal Info:
Nlm Unique ID:  101303952     Medline TA:  Gen Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Division of Cardiovascular Surgery, Funabashi Municipal Medical Center, 1-21-1 Kanasugi, Funabashi, Chiba, Japan.
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MeSH Terms
Aortic Valve Insufficiency / etiology
Aortic Valve Stenosis / etiology
Fibrosis / etiology
Heart Valve Diseases / etiology*,  surgery
Heart Valve Prosthesis Implantation
Hypertrophy / etiology
Mediastinum / radiation effects
Middle Aged
Mitral Valve Insufficiency / etiology
Pericardium / drug effects
Radiation Injuries / complications*
Tricuspid Valve Insufficiency / etiology
Comment In:
Gen Thorac Cardiovasc Surg. 2007 Aug;55(8):341   [PMID:  17867283 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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