Document Detail

Radiation-induced nerve root degeneration and hypertrophic neuropathy in the lumbosacral spinal cord of rats: the relation with changes in aging rats.
MedLine Citation:
PMID:  197774     Owner:  NLM     Status:  MEDLINE    
Three-month-old WAG/Rij rats were irradiated with 300 kV X-rays on the lumbar region of the spinal column with doses below the level for causing paralysis due to radiation radiculomyelopathy. 8--9 months after irradiation, degeneration of predominantly the ventral nerve roots of the cauda equina was boserved. Three stages were distinguishable: I) Demyelination and proliferation of Schwann cells; II) Local swelling of ventral nerve roots, with concentric layers of Schwann cells resembling hypertrophic neuropathy; III) Malignant Schwannoma, invading roots and spinal cord. It is concluded that the degenerative and proliferative lesions represent a continuous series of stages of slowly progressive lesions. The ventral nerve root degeneration (1st stage) is similar to that observed in aging, unirradiated rats, normally developing at the age of 18--20 months.
A J van der Kogel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  39     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-31     Completed Date:  1977-10-31     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
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MeSH Terms
Cauda Equina / radiation effects
Nerve Degeneration / radiation effects
Neurilemmoma / etiology
Peripheral Nervous System Diseases / etiology
Peripheral Nervous System Neoplasms / etiology
Radiation Dosage
Radiation Injuries / pathology*
Schwann Cells
Spinal Nerve Roots / radiation effects*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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