Document Detail


Radiation induced malignancy in retinoblastoma: new pathology in a case report.
MedLine Citation:
PMID:  21225836     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: Patients with a genetic history of retinoblastoma have an increased risk of developing a second neoplasm. When these secondary malignancies occur in the previously irradiated field of the primary tumor they are most commonly osteosarcomas, fibrosarcomas, and squamous cell carcinomas. We present the first case of a radiation induced adenocarcinoma in a patient after treatment for retinoblastoma.
STUDY DESIGN: A case report of one patient.
METHODS: This case study underwent a chart review, comprehensive history, physical exam, rigid nasal endoscopy, and radiographic imaging. A literature review of the MEDLINE database 1966-2009 using key words, retinoblastoma, radiation, and second malignancy was performed.
RESULTS: Our case is a 29 year old man with a past medical history significant for surgical resection followed by irradiation at age 1 for retinoblastoma who presented with right sided epistaxis and nasal obstruction. Endoscopy revealed a mass in the right nasal cavity. MRI and CT revealed a mass filling the right nasal cavity and ethmoids with erosion through the cribriform plate. The patient underwent surgical resection and pathology revealed an adenocarcinoma.
CONCLUSIONS: Second malignancies in patients with retinoblastoma tend to occur in the previously irradiated field of the primary tumour and contribute significantly to long term morbidity and mortality rates. This is the first case of a sinonasal adenocarcinoma occurring in the previously irradiated field. The endoscopic skull base surgeon plays a vital role as patient survival depends on the diagnosis and surgical management.
Authors:
Clara Draf; Madeleine R Schaberg; Vijay K Anand; Gurston Nyquist; Syed Hoda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  120 Suppl 4     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S238     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Weill Cornell Medical College, New York, NY, USA.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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