| Radiation-induced lysosomal iron reactivity: implications for radioprotective therapy. | |
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MedLine Citation:
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PMID: 16801214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel mechanism of radiosensitization involves radiation-enhanced autophagy of damaged mitochondria and various metalloproteins, by which iron accumulates within lysosomes. Hydrogen peroxide, formed by the radiolytic cleavage of water, generates in the presence of lysosomal redox-active iron extremely reactive hydroxyl radicals by Fenton-type chemistry. Subsequent peroxidative damage of lysosomal membranes initiates release of harmful content from ruptured lysosomes that triggers a cascade of events eventuating in DNA damage and apoptotic or necrotic cell death. This article reviews the role of lysosomal destabilization in radiation-induced cell damage and death. The potential effects of iron chelation therapy targeted to the lysosomes for protection of normal tissues against unwanted effects by radiation is also discussed. |
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Authors:
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H Lennart Persson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: IUBMB life Volume: 58 ISSN: 1521-6543 ISO Abbreviation: IUBMB Life Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-27 Completed Date: 2006-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888706 Medline TA: IUBMB Life Country: England |
Other Details:
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Languages: eng Pagination: 395-401 Citation Subset: IM |
Affiliation:
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Division of Pulmonary Medicine, Faculty of Health Sciences, University of Linköping, Linköping, Sweden. lenpe@inr.liu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Iron
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metabolism* Lysosomes / metabolism, radiation effects* Oxidative Stress / physiology* Radiation-Protective Agents / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Radiation-Protective Agents; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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