Document Detail

Radiation-induced arterial injuries.
MedLine Citation:
PMID:  6823669     Owner:  NLM     Status:  MEDLINE    
In a 20-year period from 1961 to 1981 at the University of Kentucky Medical Center, there were 20 patients with vascular lesions directly attributable to irradiation. Two distinct patterns of arterial injury attributable to radiotherapy were identified--arterial disruption and occlusion. Arterial disruption occurred in 12 patients--11 carotid blowouts and 1 iliac artery rupture. Two patients underwent prophylactic carotid artery ligation for impending rupture. In the 11 carotid artery ruptures, ligation of the artery in nine patients resulted in stroke or death in five patients. Iliac artery disruption necessitated ligation, which eventually led to severe ischemia requiring hip disarticulation. Unusual arterial stenosis or occlusion occurred in six patients 7 to 24 years after irradiation. Three patients had severe stenosis or occlusion of the common, internal, or external carotid arteries leading to cerebrovascular insufficiency. Three other patients with focal stenosis of the iliofemoral region were successfully treated with bypass grafting.
R A McCready; G L Hyde; B A Bivins; S S Mattingly; W O Griffen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Surgery     Volume:  93     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-12     Citation Subset:  AIM; IM    
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MeSH Terms
Arterial Occlusive Diseases / etiology*
Arteries / radiation effects*
Carcinoma, Squamous Cell / radiotherapy
Carotid Arteries / radiation effects,  radiography
Cerebrovascular Disorders / etiology
Femoral Artery / surgery
Hip Dislocation / etiology
Iliac Artery / radiation effects
Ischemia / etiology
Ligation / adverse effects
Middle Aged
Mouth Neoplasms / radiotherapy
Radiation Injuries / etiology*
Radiotherapy / adverse effects*
Rupture, Spontaneous / prevention & control
Saphenous Vein / transplantation
Uterine Cervical Neoplasms / radiotherapy
Vocal Cords / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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