Document Detail

Radiation dose to mouse liver cells from ingestion of tritiated food or water.
MedLine Citation:
PMID:  2341252     Owner:  NLM     Status:  MEDLINE    
Tritium incorporated into tissues and DNA of mice was studied after daily ingestion of tritiated food or tritiated water. The tritiated food used was a commercial preparation mixed with brine shrimp that had been reared in tritiated sea water. After ingestion of tritiated food or water for up to 22 d, the specific activity of 3H in tissues was measured as tissue-free-water 3H, tissue-bound 3H, and DNA-bound 3H. Carbon-14 glucose was added to food and drinking water to compare the 3H intake from food with that from water. The specific activity of 3H in tissues was then corrected by the specific activity of 14C in tissues to determine the 3H incorporation from the same amount of ingested food and water. DNA-bound 3H after the ingestion of tritiated food was 4.6 times higher than that of tritiated water, while tissue-bound 3H was 2.2 times higher. The radiation dose to liver from 3H incorporated through food was twofold higher than from tritiated water, which was mainly from the high incorporation of 3H into DNA. Our results demonstrated that the dose calculation based on tissue-free-water 3H alone would under-estimate the radiation exposure of the human population exposed to tritiated food.
K Komatsu; Y Okumura; K Sakamoto
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Health physics     Volume:  58     ISSN:  0017-9078     ISO Abbreviation:  Health Phys     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-26     Completed Date:  1990-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-9     Citation Subset:  IM    
Department of Radiation Biophysics, Nagasaki University School of Medicine, Japan.
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MeSH Terms
DNA / metabolism
Food Contamination, Radioactive / analysis
Liver / metabolism*
Maximum Allowable Concentration
Radiation Dosage
Time Factors
Tissue Distribution
Tritium / administration & dosage,  analysis,  pharmacokinetics*
Reg. No./Substance:
10028-17-8/Tritium; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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