Document Detail


Radiation dose to the fetus from [(18)F]-FDG administration during the second trimester of pregnancy.
MedLine Citation:
PMID:  22217594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors estimated the fetal radiation dose from [(18)F]-FDG in a rare case of a woman who underwent a PET/CT scan during the second trimester of pregnancy. The patient, a 27-y-old female with a paraganglioma, received 181.3 MBq [(18)F]-FDG. From the concentrations of radioactivity measured on the images, the time-integrated activity coefficients of the fetus and the placenta were derived. The time-integrated activity coefficients of the mother's organs were taken from the standard values of ICRP publication 106. The final fetal dose was calculated using the 6-mo pregnant model of the OLINDA/EXM software. The fetus showed an overall low and homogeneous [(18)F]-FDG uptake, with an average concentration of 2.41 kBq cm(-3). The uptake in the placenta was generally higher (average concentration = 3.69 kBq cm(-3)). The estimated time-integrated activity coefficients were 0.0130 and 0.0058 Bq h Bq(-1) for the fetus and the placenta, respectively. The final average dose to the fetus was 1.97 × 10(-2) mGy MBq(-1) (3.6 mGy in this patient who received 181.3 MBq). Therefore, the dose to the fetus from [(18)F]-FDG administration during the second trimester of pregnancy is low. When medically indicated, pregnancy should not be a categorical basis for withholding [(18)F]-FDG PET scans.
Authors:
Paolo Zanotti-Fregonara; Thomas M Koroscil; Joseph Mantil; Martin Satter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Health physics     Volume:  102     ISSN:  1538-5159     ISO Abbreviation:  Health Phys     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-05     Completed Date:  2012-02-21     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-9     Citation Subset:  IM    
Affiliation:
Molecular Imaging Branch, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD 20892-2035, USA. zanottifregonp@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetus / metabolism*
Fluorodeoxyglucose F18 / pharmacokinetics*
Humans
Positron-Emission Tomography
Pregnancy
Pregnancy Trimester, Second
Radiation Dosage*
Radiopharmaceuticals / pharmacokinetics*
Grant Support
ID/Acronym/Agency:
Z99 MH999999/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18
Comments/Corrections

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