| Radiation dose to the fetus from [18F]-FDG administration during the second trimester of pregnancy. | |
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MedLine Citation:
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PMID: 22217594 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT-: The authors estimated the fetal radiation dose from [F]-FDG in a rare case of a woman who underwent a PET/CT scan during the second trimester of pregnancy. The patient, a 27-y-old female with a paraganglioma, received 181.3 MBq [F]-FDG. From the concentrations of radioactivity measured on the images, the time-integrated activity coefficients of the fetus and the placenta were derived. The time-integrated activity coefficients of the mother's organs were taken from the standard values of ICRP publication 106. The final fetal dose was calculated using the 6-mo pregnant model of the OLINDA/EXM software. The fetus showed an overall low and homogeneous [F]-FDG uptake, with an average concentration of 2.41 kBq cm. The uptake in the placenta was generally higher (average concentration = 3.69 kBq cm). The estimated time-integrated activity coefficients were 0.0130 and 0.0058 Bq h Bq for the fetus and the placenta, respectively. The final average dose to the fetus was 1.97 × 10 mGy MBq (3.6 mGy in this patient who received 181.3 MBq). Therefore, the dose to the fetus from [F]-FDG administration during the second trimester of pregnancy is low. When medically indicated, pregnancy should not be a categorical basis for withholding [F]-FDG PET scans. |
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Authors:
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Paolo Zanotti-Fregonara; Thomas M Koroscil; Joseph Mantil; Martin Satter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Health physics Volume: 102 ISSN: 1538-5159 ISO Abbreviation: Health Phys Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985093R Medline TA: Health Phys Country: United States |
Other Details:
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Languages: eng Pagination: 217-9 Citation Subset: IM |
Affiliation:
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* Molecular Imaging Branch, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD; † Wright State University Boonshoft School of Medicine, Dayton, OH; ‡ Department of Nuclear Medicine/PET, Kettering Medical Center, Dayton, OH. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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