| Radiation and the cell cycle, revisited. | |
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MedLine Citation:
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PMID: 15197324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell cycle has been inextricably linked to the cellular response to radiation for many years. However, it is only in the past decade that the concept of a coordinated DNA damage response integrating damage recognition, cell cycle checkpoints and DNA repair has begun to be elucidated. The ATM protein is emerging as a key orchestrator of the damage response activating a wide variety of effectors involved in cell cycle arrest and DNA repair to elicit a concerted effort to prevent genome instability caused by unwanted changes in DNA sequence. The key proteins involved in cell cycle checkpoints in different phases of the cell cycle, and their interaction, is a fertile and rapidly developing area of research. This review summarizes the current state of knowledge of cellular checkpoints in response to radiation-induced double-strand breaks in mammalian cells and how this impacts on radiosensitivity. |
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Authors:
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George D Wilson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cancer metastasis reviews Volume: 23 ISSN: 0167-7659 ISO Abbreviation: Cancer Metastasis Rev. Publication Date: 2004 Aug-Dec |
Date Detail:
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Created Date: 2004-06-15 Completed Date: 2005-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605731 Medline TA: Cancer Metastasis Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 209-25 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Hudson Webber Building, Room 816, 4100 John R, Wayne State University, Detroit, MI 48201-2013, USA. wilsong@karmanos.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology*, radiation effects* DNA Damage / radiation effects DNA Repair / radiation effects Humans Proteins / metabolism Signal Transduction / radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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