| Radiation cataractogenesis induced by neutron or gamma irradiation in the rat lens is reduced by vitamin E. | |
| | |
MedLine Citation:
|
PMID: 2080428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although cataract of the eye lens is a known late effect of ionizing radiation exposure, most of the experimental work to date has concentrated on single, acute high doses or multiple, fractionated, chronic exposures. Many papers have dealt with biochemical alterations in metabolism and cellular components, with microscopic and electron microscopic lesions to the epithelial and cortical layers, and with clinical cataract formation. However, the minimum cataractogenic dose for rats has for many years been considered to be about 2 Gy for a single, acute dose of low LET radiation. Our purpose in designing this pilot study was three fold: firstly, to determine whether any physical damage could be detected after low, acute exposure to neutron radiation (10 and 100 cGy); secondly, to compare the relative effectiveness of fast (14 MeV) neutrons with gamma-rays; and thirdly, to investigate the possibility that vitamin E could protect the lenses from radiation damage. The results revealed that morphological damage was already discernible within minutes after exposure to neutrons or gamma-rays, that it became greater after 24 hours, that neutrons were more damaging than gamma-rays, and that vitamin E could effectively reduce the cataractogenic damage induced by ionizing radiation. Control, non-irradiated lenses with or without vitamin E, either in vivo or in vitro, showed no damage. Also, it appeared that in vitro irradiation was more damaging to lenses than in vivo irradiation, so this culture technique may prove to be a sensitive tool for assessing early damage caused by ionizing radiation.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
W M Ross; M O Creighton; J R Trevithick |
Related Documents
:
|
901978 - Some long-term effects of negative pions in mice exposed to partial body irradiation. 7088008 - Differential persistence of chromosomal damage induced in resting rat-liver cells by x-... 19544808 - Characterization of a mini-multileaf collimator in a proton beamline. 15214538 - The design, construction and performance of a variable collimator for epithermal neutro... 10995858 - Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine... 6356898 - Study of single and multiple dose pharmacokinetic/pharmacodynamic modeling of the antih... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Scanning microscopy Volume: 4 ISSN: 0891-7035 ISO Abbreviation: Scanning Microsc. Publication Date: 1990 Sep |
Date Detail:
|
Created Date: 1991-05-02 Completed Date: 1991-05-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8704616 Medline TA: Scanning Microsc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 641-9; discussion 649-50 Citation Subset: IM |
Affiliation:
|
Nuclear Effects (Radiobiology), Defence Research Establishment Ottawa, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cataract / etiology, prevention & control* Dose-Response Relationship, Drug Female Gamma Rays Lens, Crystalline / pathology, radiation effects*, ultrastructure Microscopy, Electron Neutrons Pilot Projects Rats Rats, Inbred Strains Vitamin E / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
1406-18-4/Vitamin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histomorphometric analysis of the rat proximal tibial metaphysis by "linear scanning".
Next Document: Intracellular penetration and accumulation of radiographic contrast media in the rat kidney.