Document Detail

Radiation-associated angiosarcoma of the small bowel. A case of multiploidy and a fulminant clinical course. Case report.
MedLine Citation:
PMID:  9048867     Owner:  NLM     Status:  MEDLINE    
Angiosarcoma developing in unusual sites such as the gastrointestinal tract is not uncommonly associated with a known eliciting factor. Thus, among hitherto reported cases of angiosarcoma of the small bowel, five were radiation-associated. One additional example of ileal angiosarcoma induced by therapeutic irradiation of endometrial carcinoma is herein reported as a reminder of this causal association. DNA analyses of the primary growth as well as the metastatic deposits showed at least four aneuploid cell clones indicating genetic instability. This observation corresponds to the consistently poor prognosis of radiation-associated angiosarcoma of the small bowel.
S H Hansen; S Holck; H Flyger; U B Tange
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  891-4     Citation Subset:  IM    
Department of Pathology, Hillerød Hospital, Denmark.
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MeSH Terms
DNA, Neoplasm / analysis
Endometrial Neoplasms / radiotherapy
Flow Cytometry
Hemangiosarcoma / etiology*,  genetics,  pathology
Ileum / radiation effects
Intestinal Neoplasms / etiology*,  genetics,  pathology
Neoplasms, Radiation-Induced* / genetics,  pathology
Radiotherapy, High-Energy / adverse effects
Reg. No./Substance:
0/DNA, Neoplasm

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