| Radiation dose to the conceptus from multidetector CT during early gestation: a method that allows for variations in maternal body size and conceptus position. | |
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MedLine Citation:
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PMID: 20807845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To develop a method for estimating the radiation dose to the conceptus from multidetector computed tomography (CT) of the abdomen and pelvis in pregnant patients during the first 7 weeks of gestation. MATERIALS AND METHODS: This study was approved by the institutional review board and informed consent was obtained. A CT simulation software package was used to (a) develop voxelized models on the basis of image data from 117 nonpregnant patients who underwent abdominal and pelvic multidetector CT and (b) calculate dose at a position of the uterus assumed to be the position of the conceptus in case of pregnancy during the first 7 weeks of gestation. Regression analysis was carried out to establish the relationship among conceptus dose, patient body size, and distance from the conceptus to the anterior skin surface. RESULTS: Normalized conceptus doses calculated by using the software package ranged from 0.335 to 0.785 mGy per absorbed dose to air. Conceptus dose showed a significant correlation with maternal body size and conceptus depth (R² = 0.793, P < .001). A multivariable correlation of conceptus dose normalized to the free-in-air CT dose index (CTDI(F)) with conceptus depth and patient perimeter was produced for estimating conceptus dose from abdominal and pelvic multidetector CT. Conceptus dose data provided for a specific scanner can be applied to other scanners by using correction factors based on ratios between the weighted CT dose index and CTDI(F), resulting in inaccuracies in the estimation of conceptus dose of less than 12%. CONCLUSION: The radiation dose to the conceptus from abdominal and pelvic multidetector CT can be estimated with a method that allows for variations in maternal body size and conceptus position. |
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Authors:
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John Damilakis; Kostas Perisinakis; Antonis Tzedakis; Antonios E Papadakis; Apostolos Karantanas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-31 |
Journal Detail:
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Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 483-9 Citation Subset: AIM; IM |
Copyright Information:
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© RSNA, 2010. |
Affiliation:
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Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Iraklion 71003, Crete, Greece. damilaki@med.uoc.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Size Computer Simulation Female Fetus / radiation effects* Humans Linear Models Monte Carlo Method Pregnancy Pregnancy Trimester, First Radiation Dosage* Regression Analysis Software Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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