Document Detail

Radiation Dose Reduction for CT-Guided Renal Tumor Cryoablation.
MedLine Citation:
PMID:  21512049     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The purpose of this article is to retrospectively determine the image quality and degree of radiation dose reduction that is clinically acceptable for CT-guided renal tumor cryoablation.
MATERIALS AND METHODS: A total of 15 patients (17 procedures; mean age, 67 years; range, 38-85 years) undergoing clinically indicated CT-guided renal tumor cryoablation procedures were included in this retrospective study. A previously validated noise-insertion tool was used to simulate reduced-dose scans at 75%, 50%, 25%, and 10% of the original dose at four representative phases of the cryoablation procedure. Images obtained at different dose levels were randomized and reviewed by three radiologists blinded to the level of dose reduction, who scored them independently with a 5-point scale (1-5, with 5 the best). Images with a mean score of 3 or higher were considered diagnostically acceptable. The minimal acceptable dose was that at which 90% of images were considered diagnostically acceptable. Interrater agreement was assessed using the weighted kappa statistic.
RESULTS: The weighted kappa value was 0.68, indicating substantial agreement among the reviewers. The averaged percentage of diagnostically acceptable images for the four series was 100% for a full dose, 98-100% for the 75% dose level, 94-98% for the 50% dose level, and less than 90% for images obtained at the 25% and 10% dose levels, which was considered unacceptable.
CONCLUSION: On the basis of results from 15 patients (17 procedures), images obtained from CT acquisitions at 50% (volume CT dose index, 12.2 mGy) of the original dose level (volume CT dose index, 24.4 mGy) were acceptable for the purpose of CT monitoring of renal cryoablation procedures.
Shuai Leng; Thomas D Atwell; Lifeng Yu; Jay Mandrekar; Bradley D Lewis; David A Woodrum; Cynthia H McCollough
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  196     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  W586-91     Citation Subset:  AIM; IM    
Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
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