Document Detail


Radial and vertebral bone density in white and black women: evidence for racial differences in premenopausal bone homeostasis.
MedLine Citation:
PMID:  2778034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reasons for a different incidence of osteoporotic fractures in white and black women are unknown. Previous racial comparisons of bone mass have been limited by racial differences in body weight and socioeconomic, health, and nutritional status. This cross-sectional study examined bone density in 105 black and 114 white healthy nonobese women, 24-65 yr old, using dual photon absorptiometry of the lumbar spine and single photon absorptiometry of the distal radius. Bone density at both sites was higher in blacks at all ages than in whites. When adjusted for age and body mass index, mean bone density was 6.5% higher in blacks at both spine and radius (P less than 0.0001). The cross-sectional rate of decline of vertebral bone density was similar between races; however, radial density increased 3.8%/decade (P = 0.03) in premenopausal blacks under age 46 yr, while it declined 3.2%/decade (P = 0.09) in premenopausal whites. The racial difference in slopes in these premenopausal women is significant (P = 0.002). These findings suggest that attainment of higher peak bone mass and delayed onset of bone loss contribute to the lower incidence of osteoporotic fractures in black women.
Authors:
M M Luckey; D E Meier; J P Mandeli; M C DaCosta; M L Hubbard; S J Goldsmith
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  69     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-10-13     Completed Date:  1989-10-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  762-70     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, Mount Sinai Medical Center, New York, New York 10029.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group*
Bone and Bones / anatomy & histology,  metabolism,  radionuclide imaging*
European Continental Ancestry Group*
Female
Homeostasis
Humans
Longitudinal Studies
Menopause*
Middle Aged
Regression Analysis
Spine / radionuclide imaging
Grant Support
ID/Acronym/Agency:
IK08-AG-00358-01/AG/NIA NIH HHS; IR01-AG-07113-01/AG/NIA NIH HHS; RR-71/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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