Document Detail


Radial glial cell heterogeneity--the source of diverse progeny in the CNS.
MedLine Citation:
PMID:  17580100     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here, we discuss the identity, heterogeneity and functions of radial glial cells mostly in the developing central nervous system (CNS). First, we define radial glial cells by morphological, cell biological and molecular criteria as true glial cells, akin to astroglia. We then describe the appearance of radial glial cells during neural development as a precursor intermediate between immature neuroepithelial cells and differentiating progeny. Then we review the diverse progeny arising in different lineages from radial glial cells as observed by clonal analyses and time-lapse imaging. This leads us to discuss the molecular mechanisms involved in the regulation of the lineage heterogeneity of radial glial cells - including their diversity in distinct regions of the CNS. We conclude by considering the possible mechanisms allowing neurogenic radial glial cells to persist into adulthood in various vertebrate classes ranging from fish to birds, while neurogenic glial cells become restricted to few small regions of the adult forebrain in mice and men.
Authors:
Luisa Pinto; Magdalena Götz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-03-07
Journal Detail:
Title:  Progress in neurobiology     Volume:  83     ISSN:  0301-0082     ISO Abbreviation:  Prog. Neurobiol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370121     Medline TA:  Prog Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2-23     Citation Subset:  IM    
Affiliation:
Institute of Stem Cell Research, GSF-National Research Center for Health and Environment, Ingolstädter Landstr. 1, D-85764 Neuherberg/München, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Cell Lineage / physiology
Central Nervous System / cytology*,  growth & development
Embryonic Stem Cells / cytology
Humans
Multipotent Stem Cells / cytology*
Neuroepithelial Cells / cytology*
Neuroglia / cytology*

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