Document Detail


Radial artery versus saphenous vein patency randomized trial: five-year angiographic follow-up.
MedLine Citation:
PMID:  18506009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Graft patency is a fundamental predictor of long-term survival after coronary artery bypass surgery. Left and right internal thoracic artery (arterial) graft patency has been shown to be superior to that of saphenous vein grafts. More recently, the radial artery has been used as an aortocoronary graft, but little is known about the midterm and long-term patency of this conduit. We performed a single-center prospective randomized trial comparing the angiographic patency of radial artery and saphenous vein aortocoronary bypass grafts at 5 years after surgery. METHODS AND RESULTS: We enrolled 142 patients randomized at a single center to have either the radial artery or saphenous vein grafted to a stenosed branch of the native left circumflex coronary artery. The primary end point was angiographic graft patency 5 years postoperatively. At 5 years, 134 patients were alive and eligible for reangiography (5-year survival, 94.4%). Angiography was performed in 103 patients (77%); 98.3% of radial artery grafts and 86.4% of saphenous vein grafts were patent (P=0.04). Graft narrowing occurred in 10% of patent radial artery grafts and 23% of patent saphenous vein grafts (P=0.01). CONCLUSIONS: Radial artery aortocoronary bypass grafts to a stenosed branch of the circumflex coronary artery have an excellent patency rate at 5 years. This was significantly better than the patency rate for saphenous vein grafts and comparable to reported patency rates for internal thoracic artery grafts.
Authors:
Peter Collins; Carolyn M Webb; Chee F Chong; Neil E Moat;
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-05-27
Journal Detail:
Title:  Circulation     Volume:  117     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2859-64     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiography
Blood Vessel Prosthesis / standards*
Blood Vessel Prosthesis Implantation
Coronary Artery Bypass
Coronary Stenosis / surgery*
Humans
Middle Aged
Radial Artery / transplantation*
Saphenous Vein / transplantation*
Treatment Outcome
Vascular Patency*
Investigator
Investigator/Affiliation:
C F Chong / ; J R Clague / ; P Collins / ; S W Davies / ; A C DeSouza / ; C S Hayward / ; S Kaddoura / ; C di Mario / ; N E Moat / ; J R Pepper / ; M Petrou / ; P Sarkar / ; D F Shore /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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