| Radial artery compliance in response to mental stress in normotensive offspring of hypertensive parents. | |
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MedLine Citation:
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PMID: 11710756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Compared to normal subjects hypertensive patients have an increased radial artery isobaric distensibility, contrasting with a decrease in elasticity of large arteries and systemic compliance. To address the question whether elasticity is increased in response to long-standing elevated blood pressure or is present at an early stage of the disease, we compared normotensive offspring of hypertensive parents with control subjects. Furthermore, enhanced sympathetic response to mental stress was demonstrated in individuals predisposed to hypertension and might contribute to the elevation of blood pressure via a peripheral mechanism. Thus, an abnormal vasoconstrictive response of the radial artery to psychological stress was sought in these subjects. DESIGN: The geometry and the elastic porperties of the radial artery were assessed in normotensive offspring of hypertensive and normotensiven parents at baseline and during mental stress. METHODS: A high-precision echo-tracking ultrasound device was combined with photoplethysmography for continuous measurement of radial artery diameter and isobaric distensibility in 18 normotensive offspring of parents with essential hypertension and 18 control subjects under resting conditions and during a 3-minute mental stress test. RESULTS: Baseline arterial distensibility and compliance were comparable in offspring of hypertensive and normotensive parents. During mental stress, blood pressure and heart rate increased similarly in both groups. Adrenergic activation did not alter the elastic properties of the radial artery in the individuals with a genetic predisposition to essential hypertension. CONCLUSIONS: There was no alteration in elastic properties of the radial artery in normotensiven individuals at genetic risk to develop arterial hypertension. Furthermore, mental stress did not abnormally increase the vascular tone of this medium-sized muscular artery in these subjects as compared to controls. This indicates that functional and/or structural vascular alterations do not precede a distinct rise in blood pressure or abnormal blood pressure reactivity in subjects prone to develop essential hypertension. |
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Authors:
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E Delacrétaz; D Hayoz; D Hutter; Y Allemann |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 23 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-16 Completed Date: 2002-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 545-53 Citation Subset: IM |
Affiliation:
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Swiss Cardiovascular Center Bern, University of Bern. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Case-Control Studies Compliance Family Humans Hypertension / genetics* Male Photoplethysmography / methods Radial Artery / physiology*, ultrasonography Stress, Psychological / physiopathology* Ultrasonography / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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