| Radial artery compliance in essential hypertension: effects of antihypertensive therapy with lacidipine. | |
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MedLine Citation:
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PMID: 8169377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effects of antihypertensive therapy with lacidipine on the increase in radial artery compliance observed in mild essential hypertensive patients. METHODS: The study was performed in eight mild to moderate essential hypertensive patients in whom clinic blood pressure, radial artery diameter and radial artery compliance were evaluated before and after 3 months' administration of lacidipine, at a single daily dose of 4 mg. Radial artery diameter and compliance were evaluated by means of a high precision echo-tracking device able to assess arterial compliance over the blood pressure oscillations that characterize the cardiac cycle. RESULTS: Lacidipine treatment caused a significant reduction in clinic systolic and diastolic blood pressure, while the heart rate was not modified by the drug. Radial artery diameter and compliance were both reduced by lacidipine over the entire systolodiastolic blood pressure range. CONCLUSIONS: Chronic administration of lacidipine seems to reverse the increase in compliance observed in essential hypertension at the radial artery level. We suggest that lacidipine treatment can reverse an increase in the smooth muscle component in the arterial wall induced by hypertension. |
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Authors:
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S Trazzi; C Santucciu; G Mancia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 11 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-06-02 Completed Date: 1994-06-02 Revised Date: 2005-06-08 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S17-20 Citation Subset: IM |
Affiliation:
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Cattedra di Medicina Interna I, Ospedale S. Gerardo, Monza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / pharmacology, therapeutic use Blood Pressure / drug effects Calcium Channel Blockers / pharmacology, therapeutic use Dihydropyridines / pharmacology, therapeutic use* Female Humans Hypertension / drug therapy*, physiopathology* Male Middle Aged Radial Artery / drug effects*, physiopathology Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Dihydropyridines; 103890-78-4/lacidipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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