Document Detail


Radial aplasia and amegakaryocytic thrombocytopenia (TAR syndrome) among Nigerian children.
MedLine Citation:
PMID:  6702785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five patients with radial aplasia studied during a period of ten years at the University College Hospital, Ibadan, Nigeria, had the amegakaryocytic thrombocytopenia syndrome. Together, they are termed the TAR syndrome. Two of the five patients were siblings from a polygamous family; three patients had relative hypogammaglobulinemia, and one of these patients had late onset of congenital varicella. The findings in these five cases led to further understanding of the genetic mechanisms of the TAR syndrome. Furthermore, the high incidence of infection associated with the syndrome could be partially explained by hypogammaglobulinemia.
Authors:
A A Adeyokunnu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  138     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-04-25     Completed Date:  1984-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / pathology
Adult
Agammaglobulinemia / complications
Female
Humans
Infant, Newborn
Male
Megakaryocytes / pathology*
Nigeria
Osteoarthropathy, Secondary Hypertrophic / genetics,  pathology
Radius / abnormalities*,  radiography
Syndrome
Thrombocytopenia / genetics,  pathology*

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