Document Detail

Racial variation in vitamin D cord blood concentration in white and black male neonates.
MedLine Citation:
PMID:  23139102     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study is to evaluate racial variation in umbilical cord blood concentration of vitamin D and to explore its correlation with markers of the insulin-like growth factor axis (IGFs) and sex steroid hormones in white and black male neonates.
METHODS: In 2004-2005, venous umbilical cord blood samples were collected from 75 black and 38 white male neonates, along with maternal and birth characteristics from two hospitals in Maryland, United States. 25-Hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] were measured by radioimmunoassay and testosterone, estradiol, and sex hormone-binding globulin (SHBG) by immunoassay and IGF-1, IGF-2, and IGF-binding protein-3 by ELISA. Crude and multivariable-adjusted geometric mean concentrations were computed.
RESULTS: Mean 25(OH)D levels were lower in black than in white neonates (11.44; 95 % CI 10.10-12.95 ng/mL vs. 18.24; 95 % CI 15.32-21.72 ng/mL; p < 0.0001). Black neonates were at higher risk of suboptimal vitamin D levels [25(OH)D < 20 ng/mL] than whites (84 vs. 63 %). 25(OH)D concentrations varied by season in whites but not in blacks and were significantly inversely correlated with mother's parity (number of live births) in blacks but not in whites. Mean concentration of 1,25(OH)(2)D did not differ by race. 25(OH)D and 1,25(OH)(2)D did not correlate with IGFs, sex steroid hormones, and SHBG.
CONCLUSIONS: Suboptimal vitamin D levels were prevalent especially in blacks and influenced by mother's parity and by season. The observed vitamin D differences between black and white neonates warrant further evaluation of the etiology of the disparity in chronic diseases in adulthood.
Monika Eichholzer; Elizabeth A Platz; Jessica L Bienstock; Deborah Monsegue; Folasade Akereyeni; Bruce W Hollis; Ronald Horst; Nader Rifai; Michael N Pollak; Aline Barbir; Tanya Agurs-Collins; Sabine Rohrmann
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-09
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  24     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-05-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  IM    
Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Hirschengraben 84, Zürich, Switzerland.
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MeSH Terms
African Continental Ancestry Group* / statistics & numerical data
Continental Population Groups / statistics & numerical data
European Continental Ancestry Group* / statistics & numerical data
Fetal Blood / chemistry*,  metabolism
Infant, Newborn / blood*,  metabolism
Maryland / epidemiology
Osmolar Concentration
United States / epidemiology
Vitamin D / analysis,  blood*,  metabolism
Young Adult
Grant Support
U54 CA091409/CA/NCI NIH HHS; U54 CA091409/CA/NCI NIH HHS; U54 CA091431/CA/NCI NIH HHS
Reg. No./Substance:
1406-16-2/Vitamin D

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