Document Detail


Racial variation in the relationship of anemia with mortality and mobility disability among older adults.
MedLine Citation:
PMID:  17284526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anemia is more common among older blacks than older whites. However, it is unclear whether anemia predicts adverse events similarly in both races. Data on 1018 black and 1583 white adults aged 71 to 82 years were analyzed. Anemia, as defined by World Health Organization (WHO) criteria, was used to predict mortality over 6 years and incidence of mobility disability over 4 years. In proportional hazards models of mortality in whites, the age-adjusted hazard ratio (HR) for anemia in men was 1.96 (95% confidence interval [CI]: 1.35, 2.83) and in women was 2.86 (95% CI: 1.69, 4.82). In contrast, anemia was not associated with mortality in black men (HR = 1.15 [95% CI: 0.77, 1.72]) or women (HR = 1.39 [95% CI: 0.91, 2.14]). Higher mortality rate was observed only in black men with hemoglobin values more than 20 g/L (2.0 g/dL) below the WHO cutoff, whereas mortality rates were elevated in white men with hemoglobin values 1 to 10, 11 to 20, and more than 20 g/L below the WHO cutoff. In conclusion, anemia was significantly associated with increased risk of death and mobility disability in community-dwelling older whites. Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted.
Authors:
Kushang V Patel; Tamara B Harris; Marion Faulhaber; Sara B Angleman; Stephanie Connelly; Douglas C Bauer; Lewis H Kuller; Anne B Newman; Jack M Guralnik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-02-06
Journal Detail:
Title:  Blood     Volume:  109     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-24     Completed Date:  2007-07-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4663-70     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging/NIH, Bethesda, MD 20892, USA. patelku@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Aged
Aging*
Anemia / complications,  ethnology*,  mortality*
Cohort Studies
European Continental Ancestry Group
Female
Hemoglobins / biosynthesis,  metabolism
Humans
Male
Mobility Limitation
Proportional Hazards Models
Risk Factors
Sex Factors
Time Factors
Grant Support
ID/Acronym/Agency:
N01 AG 62101/AG/NIA NIH HHS; N01 AG 62103/AG/NIA NIH HHS; N01 AG 62106/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins
Comments/Corrections
Comment In:
Blood. 2008 Mar 1;111(5):2941; author reply 2941-2   [PMID:  18299454 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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