| Racial-ethnic differences in incident olanzapine use after an FDA advisory for patients with schizophrenia. | |
| | |
MedLine Citation:
|
PMID: 23280461 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Prior investigations suggest that olanzapine use declined rapidly after a U.S. Food and Drug Administration (FDA) communication and consensus statement warning of the drug's increased metabolic risks, but whether declines differed by racial-ethnic groups is unknown. METHODS: Changes in olanzapine use over time by race-ethnicity was assessed among 7,901 Florida Medicaid enrollees with schizophrenia. RESULTS: Prior to the advisory, 57% of second-generation antipsychotic fills among Hispanics were for olanzapine, compared with 40% for whites or blacks (adjusted risk difference [ARD]=.17, 95% confidence interval [CI]=.13-.20). Olanzapine use declined among all racial-ethnic groups. Although Hispanics had greater olanzapine use than whites in each period, the differences in absolute risk were only 3% by the latest study period (ARD=.03, CI=.01-.04). CONCLUSIONS: After the FDA communication and consensus statement were issued, differences in olanzapine use between white and Hispanic enrollees narrowed considerably. Identifying high-use subgroups for targeted delivery of drug safety information may help eliminate any existing differences in prescribing. |
| | |
Authors:
|
Stacie B Dusetzina; Benjamin L Cook; Alisa B Busch; G Caleb Alexander; Haiden A Huskamp |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Psychiatric services (Washington, D.C.) Volume: 64 ISSN: 1557-9700 ISO Abbreviation: Psychiatr Serv Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9502838 Medline TA: Psychiatr Serv Country: United States |
Other Details:
|
Languages: eng Pagination: 83-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Disparities in unmet need for mental health services in the United States, 1997-2010.
Next Document: Substance screening and referral for substance abuse treatment in an integrated mental health care p...