| Racial and ethnic differences in albuminuria in individuals with estimated GFR greater than 60 mL/min/1.73 m(2): results from the Kidney Early Evaluation Program (KEEP). | |
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MedLine Citation:
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PMID: 20172444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Albuminuria is an important marker for chronic kidney disease and progression to end-stage renal disease in the general population; understanding racial and ethnic differences can help inform efforts to reduce health disparities. We sought to estimate independent associations of race/ethnicity with albuminuria to determine whether observed differences were attributable to known kidney disease risk factors. METHODS: This cross-sectional study included 64,161 Kidney Early Evaluation Program (KEEP) participants, 2000-2008, with estimated glomerular filtration rate > or = 60 mL/min/1.73 m(2), not on regular dialysis therapy, and without a previous kidney transplant. Albuminuria (urine albumin-creatinine ratio > or = 30 mg/g) was examined by self-reported race and ethnicity. Covariates were age, sex, educational level, body mass index, diabetes status or glucose level, hypertension status or blood pressure measurement, smoking status, health insurance status, and geographic region. RESULTS: Albuminuria prevalences were 8% (n = 2,303) in whites, 11% (n = 2,310) in African Americans, 9% (n = 730) in Hispanics, 10% (n = 381) in Asians, and 15% (n = 344) in American Indians/Alaska Natives. Compared with whites, odds of albuminuria were higher for all groups after multivariate adjustment. Odds were highest for American Indians/Alaska Natives (adjusted OR, 1.93; 95% CI, 1.70-2.20), then Asians (adjusted OR, 1.42; 95% CI, 1.26-1.61), African Americans (adjusted OR, 1.38; 95% CI, 1.29-1.47), and Hispanics (adjusted OR, 1.19; 95% CI, 1.08-1.31). CONCLUSIONS: In the KEEP study population, albuminuria prevalence was higher in African Americans, Hispanics, Asians, and American Indians/Alaska Natives than in non-Hispanic whites, suggesting a need for screening for early detection of kidney damage, especially in people at increased risk, in the community primary care setting. |
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Authors:
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Stacey E Jolly; Nilka R?os Burrows; Shu-Cheng Chen; Suying Li; Claudine T Jurkovitz; Andrew S Narva; Keith C Norris; Michael G Shlipak |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 55 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-03-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: S15-22 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 National Kidney Foundation, Inc. All rights reserved. |
Affiliation:
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General Internal Medicine, Cleveland Clinic Medicine Institute, Cleveland, OH. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Albuminuria / diagnosis, ethnology*, physiopathology Community Health Services / methods, statistics & numerical data Continental Population Groups / ethnology* Cross-Sectional Studies Ethnic Groups / ethnology* Female Foundations* Glomerular Filtration Rate / physiology* Humans Male Mass Screening / methods, statistics & numerical data Middle Aged Risk Factors Time Factors United States / ethnology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK 066488/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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