Document Detail


Racial disparities in colorectal cancer incidence by type 2 diabetes mellitus status.
MedLine Citation:
PMID:  23197224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Type 2 diabetes mellitus (T2DM) prevalence has increased dramatically in the United States since the early 1970s. Though T2DM is known to be associated with colorectal cancer (CRC), information on racial differences in the relationship between T2DM and CRC is limited.
METHODS: Using a retrospective cohort design, we compared the association between T2DM and CRC, including subsites of the colon, in African Americans (AAs) and European Americans (EAs) in South Carolina, a region with large racial disparities in rates of both diseases. A total of 91,836 individuals who were ≥30 years old on 1 January 1990 and had ≥12 months of South Carolina Medicaid eligibility between 1 January 1990 and 31 December 1995 were included in the analyses. Cancer data from 1996 to 2007 included information on anatomic subsite.
RESULTS: Subjects who had T2DM (n = 6,006) were >50 % more likely to be diagnosed with colon cancer compared to those without T2DM (n = 85,681). The association between T2DM and colon cancer was higher in AAs [odds ratio (OR) = 1.72 (95 % confidence interval: 1.21, 2.46); n = 47,984] than among EAs (OR = 1.24; 0.73, 2.11; n = 43,703). Overall, individuals with T2DM were over twice as likely to be diagnosed with in situ or local colon cancer (OR = 2.12; 1.40, 3.22; n = 191) compared to those without T2DM, with a higher likelihood among AAs (OR = 2.49; 1.52, 4.09; n = 113).
CONCLUSIONS: Results from a Medicaid population in a high-risk region of the United States showed an increased likelihood of CRC with T2DM and suggest a racial disparity that disfavors AAs and provides further impetus for efforts aimed at diabetes prevention in this group.
Authors:
Philip P Cavicchia; Swann Arp Adams; Susan E Steck; James R Hussey; Jihong Liu; Virginie G Daguisé; James R Hebert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-11-30
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  24     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-10-30     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  277-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans / statistics & numerical data*
Cohort Studies
Colorectal Neoplasms / epidemiology,  ethnology*,  pathology
Diabetes Mellitus, Type 2 / epidemiology,  ethnology*,  pathology
European Continental Ancestry Group / statistics & numerical data*
Female
Humans
Incidence
Male
Middle Aged
Retrospective Studies
Risk Factors
South Carolina / epidemiology
Grant Support
ID/Acronym/Agency:
1U54 CA153461/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS; U54 CA153461/CA/NCI NIH HHS; U55CCU421931//PHS HHS
Comments/Corrections

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