| Racial differences in the predictive value of the TDx fetal lung maturity assay. | |
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MedLine Citation:
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PMID: 8694078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Black newborns have lower rates of neonatal respiratory distress syndrome compared with nonblack newborns. This has been attributed to accelerated lung maturation. Previous studies have demonstrated a difference in the predictive value of the lecithin/sphingomyelin ratio, a test for lung maturity, between races. Our study examines the predictive value of the newer TDx Fetal Lung Maturity Surfactant-to-Albumin assay. STUDY DESIGN: We reviewed the records of 393 nonblack and 87 black infants delivered within 72 hours of the TDx FLM S/A assay testing. We compared the rates of neonatal respiratory distress syndrome by race, stratified by results. RESULTS: In our study population black newborns had less than one half the rate of respiratory distress syndrome compared with nonblack newborns (4.6% vs 10.4%). To adjust for possible differences in the timing of lung maturation, the results were stratified by the TDx FLM S/A assay result. Black race had a protective effect (Mantel-Haenszel weighted odds ratio 0.30, 95% confidence interval 0.06 to 0.93, p < 0.05). This significant racial difference remained when both TDx FLM S/A assay result and gestational age were controlled in a multiple logistic regression analysis. CONCLUSIONS: There are differences in the predictive value of the TDx FLM S/A assay among races. Black fetuses are less likely to have respiratory distress syndrome. The difference in rates of respiratory distress syndrome between races must be due to either a qualitative difference in the surfactant or to an anatomic difference in fetal lungs. Consideration should be given to a lower cutoff value for a mature test result in black women. |
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Authors:
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S Berman; M J Tanasijevic; J G Alvarez; J Ludmir; E Lieberman; D K Richardson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 175 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-27 Completed Date: 1996-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Continental Population Groups* Female Fetal Organ Maturity Gestational Age Humans Incidence Infant, Newborn Lung / embryology* Male Predictive Value of Tests Regression Analysis Respiratory Distress Syndrome, Newborn / epidemiology, ethnology, physiopathology* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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