| Racial differences in parathyroid hormone levels in patients with secondary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 11837801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: African-Americans (AA) with normal renal function have higher parathyroid hormone (PTH) levels than Caucasians (C). This difference was also noted in cross-sectional studies of patients on dialysis. In this study, we evaluated patients with end-stage renal disease who have just began dialysis and who were not receiving any vitamin D therapy. METHODS: A total of 363 patients were recruited (C: 260; AA: 103). All patients had serum calcium, phosphorus, alkaline phosphatase and intact PTH (iPTH) levels measured within 3 months of initiating dialysis. RESULTS: Serum PTH levels were significantly higher in AA vs. C (383 +/- 33 vs. 246 +/- 19, p < 0.001). This difference was present despite similar calcium, phosphorus and alkaline phosphatase levels between the 2 groups and regardless of gender or diabetes status. However, PTH levels in patients younger than 47 years of age were similar in both groups. CONCLUSION: PTH levels in ESRD patients over 47 years of age are higher in AA compared to C. The difference is, in part, due to an age-dependent reduction in PTH seen only in C. Further studies are needed to understand the mechanisms of these racial differences and to verify whether they mirror similar alterations at the level of the end-organ tissue. |
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Authors:
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B P Sawaya; M C Monier-Faugere; P Ratanapanichkich; R Butros; P J Wedlund; P Fanti |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical nephrology Volume: 57 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-02-11 Completed Date: 2002-09-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington 40536, USA. besawa0@uky.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group* Aged Aged, 80 and over Cross-Sectional Studies Data Interpretation, Statistical European Continental Ancestry Group* Female Humans Hyperparathyroidism, Secondary / blood*, ethnology, etiology Kidney Failure, Chronic / blood*, complications, ethnology Male Middle Aged Parathyroid Hormone / blood* Renal Dialysis United States / ethnology |
| Grant Support | |
ID/Acronym/Agency:
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R21-AT00323-01/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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