Document Detail


Racial differences in parathyroid hormone levels in patients with secondary hyperparathyroidism.
MedLine Citation:
PMID:  11837801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: African-Americans (AA) with normal renal function have higher parathyroid hormone (PTH) levels than Caucasians (C). This difference was also noted in cross-sectional studies of patients on dialysis. In this study, we evaluated patients with end-stage renal disease who have just began dialysis and who were not receiving any vitamin D therapy. METHODS: A total of 363 patients were recruited (C: 260; AA: 103). All patients had serum calcium, phosphorus, alkaline phosphatase and intact PTH (iPTH) levels measured within 3 months of initiating dialysis. RESULTS: Serum PTH levels were significantly higher in AA vs. C (383 +/- 33 vs. 246 +/- 19, p < 0.001). This difference was present despite similar calcium, phosphorus and alkaline phosphatase levels between the 2 groups and regardless of gender or diabetes status. However, PTH levels in patients younger than 47 years of age were similar in both groups. CONCLUSION: PTH levels in ESRD patients over 47 years of age are higher in AA compared to C. The difference is, in part, due to an age-dependent reduction in PTH seen only in C. Further studies are needed to understand the mechanisms of these racial differences and to verify whether they mirror similar alterations at the level of the end-organ tissue.
Authors:
B P Sawaya; M C Monier-Faugere; P Ratanapanichkich; R Butros; P J Wedlund; P Fanti
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical nephrology     Volume:  57     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-11     Completed Date:  2002-09-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington 40536, USA. besawa0@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group*
Aged
Aged, 80 and over
Cross-Sectional Studies
Data Interpretation, Statistical
European Continental Ancestry Group*
Female
Humans
Hyperparathyroidism, Secondary / blood*,  ethnology,  etiology
Kidney Failure, Chronic / blood*,  complications,  ethnology
Male
Middle Aged
Parathyroid Hormone / blood*
Renal Dialysis
United States / ethnology
Grant Support
ID/Acronym/Agency:
R21-AT00323-01/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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