Document Detail

Racial differences in cardiac structure and function in essential hypertension.
MedLine Citation:
PMID:  8068083     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess racial differences in cardiac structure and function in patients presenting with previously untreated hypertension. DESIGN: Untreated black patients with hypertension were compared with untreated white patients matched for age and sex. Both groups had similar body mass indices, blood pressures, and reported duration of hypertension. SETTING: Cardiovascular risk factor clinic for outpatients. SUBJECTS: 36 men and 22 women with untreated essential hypertension. MAIN OUTCOME MEASURES: Variables of heart structure and function on cross sectional and Doppler echocardiography. RESULTS: The black patients had a significantly greater interventricular septal thickness (mean 1.23 (95% confidence interval 1.14 to 1.33) v 1.09 (1.02 to 1.16) cm; P = 0.02) and posterior wall thickness (mean 1.14 (1.07 to 1.22) v 0.96 (0.88 to 1.03) cm; P = 0.001) than the white patients, although left ventricular internal diameter was not significantly different (mean 4.90 (4.68 to 5.12) v 4.82 (4.64 to 5.01) cm; P = 0.59). This resulted in a significantly greater left ventricular mass index (mean 151 (137 to 164) v 120 (107 to 133) g/m2; P = 0.001) and relative wall thickness (mean 0.47 (0.43 to 0.51) v 0.40 (0.37 to 0.42) cm; P = 0.004) in the black patients. Comparison of Doppler measures of left ventricular diastolic function showed a significantly longer isovolumic relaxation time in black patients (mean 107 (98 to 116) v 92 (83 to 101) ms; P = 0.02) compared with white patients, although peak early to atrial filling ratios were similar in both groups (mean 1.14 (0.95 to 1.32) v 1.04 (0.94 to 1.15); P = 0.37). CONCLUSION: Among previously untreated hypertensive patients, black subjects compared with white subjects have significantly higher left ventricular mass index and relative wall thickness, as well as more impairment of left ventricular function during diastole.
J Mayet; M Shahi; R A Foale; N R Poulter; P S Sever; S A McG Thom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  308     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1011-4     Citation Subset:  AIM; IM    
Department of Cardiology, St Mary's Hospital Medical School, London.
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MeSH Terms
African Continental Ancestry Group*
Blood Pressure
Cross-Sectional Studies
Echocardiography, Doppler
European Continental Ancestry Group*
Heart Atria / physiopathology
Heart Rate
Heart Septum / ultrasonography
Hypertension / ethnology*,  physiopathology,  ultrasonography
Middle Aged
Ventricular Function, Left
Comment In:
BMJ. 1994 Jun 18;308(6944):1634-5   [PMID:  8025436 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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