| Racial differences in blood pressure response to calcium channel blocker monotherapy: a meta-analysis. | |
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MedLine Citation:
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PMID: 19498341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A systematic literature review was conducted to determine whether US blacks and whites have differential blood pressure (BP) response to calcium channel blocker (CCB) monotherapy. METHODS: Six published studies made up the final cohort of eligible articles. Multiple treatment groups within some studies led to a total of eight sets of estimates for BP reduction with a total of 6,851 white or nonblack participants and 3,371 black participants. RESULTS: The pooled difference in systolic blood pressure (SBP) change between blacks and whites was -2.7 mm Hg (95% confidence interval (CI): -4.0, -1.3) with blacks having greater response. The difference in diastolic blood pressure (DBP) between blacks and whites was -0.4 mm Hg (95% CI: -1.0, 0.3) with blacks having greater response. Using a dichotomous outcome measure, whites were found to be just as likely as blacks to attain the DBP goal of <90 mm Hg or a 10 mm Hg or greater change (relative risk: 1.00 95% CI: 0.91, 1.11). In addition, examination of the continuous distribution of BP responses of whites and blacks showed over 90% overlap in treatment response. CONCLUSION: Assessment of differential response to CCB monotherapy by race in published data depends on choice of outcome metric. Nonetheless, the results of this systematic review indicate that BP response is qualitatively similar in US blacks and whites, suggesting that patient race is not likely to offer any clinical utility for decisions about the likely effect of this antihypertensive therapy. |
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Authors:
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Thu T Nguyen; Jay S Kaufman; Eric A Whitsel; Richard S Cooper |
Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review Date: 2009-06-04 |
Journal Detail:
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Title: American journal of hypertension Volume: 22 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2009-10-05 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 911-7 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Algorithms Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects* Calcium Channel Blockers / therapeutic use* Data Interpretation, Statistical Ethnic Groups European Continental Ancestry Group Humans Hypertension / drug therapy*, epidemiology* United States |
| Grant Support | |
ID/Acronym/Agency:
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R24 HD050924-06/HD/NICHD NIH HHS; R24 HD050924-07/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2010 Mar;23(3):218; author reply 219
[PMID:
20154647
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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