Document Detail


Racial differences in blood pressure response to calcium channel blocker monotherapy: a meta-analysis.
MedLine Citation:
PMID:  19498341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A systematic literature review was conducted to determine whether US blacks and whites have differential blood pressure (BP) response to calcium channel blocker (CCB) monotherapy.
METHODS: Six published studies made up the final cohort of eligible articles. Multiple treatment groups within some studies led to a total of eight sets of estimates for BP reduction with a total of 6,851 white or nonblack participants and 3,371 black participants.
RESULTS: The pooled difference in systolic blood pressure (SBP) change between blacks and whites was -2.7 mm Hg (95% confidence interval (CI): -4.0, -1.3) with blacks having greater response. The difference in diastolic blood pressure (DBP) between blacks and whites was -0.4 mm Hg (95% CI: -1.0, 0.3) with blacks having greater response. Using a dichotomous outcome measure, whites were found to be just as likely as blacks to attain the DBP goal of <90 mm Hg or a 10 mm Hg or greater change (relative risk: 1.00 95% CI: 0.91, 1.11). In addition, examination of the continuous distribution of BP responses of whites and blacks showed over 90% overlap in treatment response.
CONCLUSION: Assessment of differential response to CCB monotherapy by race in published data depends on choice of outcome metric. Nonetheless, the results of this systematic review indicate that BP response is qualitatively similar in US blacks and whites, suggesting that patient race is not likely to offer any clinical utility for decisions about the likely effect of this antihypertensive therapy.
Authors:
Thu T Nguyen; Jay S Kaufman; Eric A Whitsel; Richard S Cooper
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-04
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-05     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  911-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Algorithms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Calcium Channel Blockers / therapeutic use*
Data Interpretation, Statistical
Ethnic Groups
European Continental Ancestry Group
Humans
Hypertension / drug therapy*,  epidemiology*
United States
Grant Support
ID/Acronym/Agency:
R24 HD050924/HD/NICHD NIH HHS; R24 HD050924-06/HD/NICHD NIH HHS; R24 HD050924-07/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers
Comments/Corrections
Comment In:
Am J Hypertens. 2010 Mar;23(3):218; author reply 219   [PMID:  20154647 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maternal endothelial progenitor colony-forming units with macrophage characteristics are reduced in ...
Next Document:  Prognostic value of different indices of blood pressure variability in hypertensive patients.