Document Detail


Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program.
MedLine Citation:
PMID:  21051082     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Biologic factors are known to contribute to asthma severity. It is unknown whether these factors differentially contribute to asthma severity in black compared with white subjects.
OBJECTIVE: We sought to assess the extent to which racial disparities between black and white subjects with severe asthma are attributable to physiologic, immunoinflammatory, and sociodemographic variables.
METHODS: Black and white asthmatic adults enrolled in a cross-sectional study focused on severe asthma were evaluated. Severe asthma was identified by using the American Thoracic Society definition. After initial univariable analyses, unconditional logistic regression models were used to estimate the probability of having severe asthma for black and white subjects.
RESULTS: Differences in severe asthma in black compared with white subjects were observed. In univariable analysis IgE level was not associated with severe asthma in black or white subjects, whereas in multivariable analysis IgE level was significantly associated with severe asthma for black subjects (P = .014) but not for white subjects. The odds of having severe asthma more than doubled for black subjects with 2 or more family members with asthma (P = .026), whereas the odds of severe asthma for white participants with a strong family history of asthma decreased by almost half (P = .05). Atopy was negatively associated with severe asthma in both races in univariable analysis but remained significant only in black subjects, whereas comorbidities were associated with severe asthma in white subjects.
CONCLUSION: Biologic factors were distinctly associated with severe asthma only in black subjects. Studies that incorporate comprehensive evaluation of biologic factors associated with asthma might lead to the development of therapies that target biologic abnormalities in black subjects.
Authors:
Christy Gamble; Evelyn Talbott; Ada Youk; Fernando Holguin; Bruce Pitt; Lori Silveira; Eugene Bleecker; William Busse; William Calhoun; Mario Castro; Kian Fan Chung; Serpil Erzurum; Elliot Israel; Sally Wenzel
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2010-11-04
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-07     Completed Date:  2011-04-05     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1149-56.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group*
Asthma / diagnosis*,  epidemiology*,  immunology,  physiopathology
Child
Child, Preschool
Disease Progression
European Continental Ancestry Group*
Female
Humans
Immunoglobulin E / immunology*
Male
Prognosis
Risk Factors
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
1UL1RR024153/RR/NCRR NIH HHS; 1UL1RR024989/RR/NCRR NIH HHS; 1UL1RR024992/RR/NCRR NIH HHS; 1UL1RR025011/RR/NCRR NIH HHS; HL091762/HL/NHLBI NIH HHS; HL69116/HL/NHLBI NIH HHS; HL69130/HL/NHLBI NIH HHS; HL69155/HL/NHLBI NIH HHS; HL69167/HL/NHLBI NIH HHS; HL69170/HL/NHLBI NIH HHS; HL69174/HL/NHLBI NIH HHS; HL69349/HL/NHLBI NIH HHS; M01 RR007122-14/RR/NCRR NIH HHS; M01 RR02635/RR/NCRR NIH HHS; M01RR03186/RR/NCRR NIH HHS; R01 HL069174/HL/NHLBI NIH HHS; R01 HL069174-01S1/HL/NHLBI NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E
Comments/Corrections

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