Document Detail


Racial differences between blacks and whites with systemic sclerosis.
MedLine Citation:
PMID:  22955018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Racial disparities appear to exist in the susceptibility and severity of systemic sclerosis (SSc, scleroderma) and are responsible for a greater health burden in blacks as compared with whites. Disparities in socioeconomic status and access to healthcare do not sufficiently explain the observed differences in prevalence and mortality. It is important to determine whether there might be a biologic basis for the racial disparities observed in SSc.
RECENT FINDINGS: We present data to suggest that the increased susceptibility and severity of SSc in blacks may result in part from an imbalance of profibrotic and antifibrotic factors. Racial differences in the expression of transforming growth factor-β1 (TGF-β1) and caveolin-1, as well as differences in the expression of hepatocyte growth factor and PPAR-γ, have been demonstrated in blacks with SSc, as well as in normal black individuals. A genetic predisposition to fibrosis may account for much of the racial disparities between black and white patients with SSc.
SUMMARY: A better understanding of the biologic basis for the racial disparities observed in SSc may lead to improved therapies, along with the recognition that different therapies may need to be adapted for different groups of patients.
Authors:
Richard M Silver; Galina Bogatkevich; Elena Tourkina; Paul J Nietert; Stanley Hoffman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  24     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-02-19     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  642-8     Citation Subset:  IM    
Affiliation:
Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. silverr@musc.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans / ethnology*,  genetics
Caveolin 1 / genetics
Disease Susceptibility / ethnology
European Continental Ancestry Group / ethnology*,  genetics
Genetic Predisposition to Disease / ethnology,  genetics
Health Status Disparities*
Hepatocyte Growth Factor / genetics
Humans
PPAR gamma / genetics
Scleroderma, Systemic / ethnology*,  genetics,  therapy
Transforming Growth Factor beta1 / genetics
Grant Support
ID/Acronym/Agency:
K01 AR051052-05/AR/NIAMS NIH HHS; K01 AR054143/AR/NIAMS NIH HHS; P60 AR049459/AR/NIAMS NIH HHS; P60 AR049459-05/AR/NIAMS NIH HHS; P60 AR062755/AR/NIAMS NIH HHS; R01 HL73718/HL/NHLBI NIH HHS; R03 AR056767/AR/NIAMS NIH HHS; R21 AT004450/AT/NCCAM NIH HHS; U01 HL060750/HL/NHLBI NIH HHS; UL1 RR029882/RR/NCRR NIH HHS; UL1RR029882/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Caveolin 1; 0/PPAR gamma; 0/Transforming Growth Factor beta1; 67256-21-7/Hepatocyte Growth Factor
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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