| Racial (black-white) differences in serum lipoprotein (a) distribution and its relation to parental myocardial infarction in children. Bogalusa Heart Study. | |
| | |
MedLine Citation:
|
PMID: 1829398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The value of lipoprotein (a) [Lp(a)] in the prediction of coronary artery disease risk very early in life remains to be established in different racial groups. METHODS AND RESULTS: Serum Lp(a) distribution and its relation to parental histories of myocardial infarction were examined in 2,438 children (8-17 years old) from a biracial community. Parental myocardial infarction was used as a surrogate measure of future risk of disease in the offspring. Lp(a) levels averaged 1.7-fold higher in blacks than in whites (p less than 0.0001). A small but significant sex difference (females greater than males, p less than 0.05) was seen in both races. Race was the only independent variable that contributed appreciably (9%) to the variability of Lp(a) in serum. White children with parental myocardial infarction (n = 90) had increased levels of Lp(a) compared with those without parental myocardial infarction (22.4 versus 17.1 mg/dl, p less than 0.01). Furthermore, among white children, the prevalence of parental myocardial infarction was higher in those with Lp(a) levels of more than 25 mg/dl than in those with values of 25 mg/dl or less (9.5% versus 5.4%, p less than 0.01). In contrast, the relation of Lp(a) to parental myocardial infarction was not seen in black children. No associations were observed between parental myocardial infarction and serum levels of any of the lipids or lipoprotein cholesterol classes in children of either race. CONCLUSIONS: Serum Lp(a) levels may prove valuable in the assessment of coronary artery disease risk early in life among white populations. These findings also emphasize the need to evaluate the atherogenic potential of Lp(a) in different racial groups. |
| | |
Authors:
|
S R Srinivasan; G H Dahlen; R A Jarpa; L S Webber; G S Berenson |
Related Documents
:
|
4057538 - Applications of anticardiac myosin monoclonal antibodies in the diagnosis of heart dise... 12918638 - Tryptase levels in patients after acute coronary syndromes: the potential new marker of... 7860468 - Changes in 6 keto pgf1 alpha and txb2 in patients with myocardial infarction. 17423238 - Monensin poisoning in horses - an international incident. 1831068 - Left ventricular diastolic function in athletes and borderline hypertensives with mild ... 2049888 - The s wave in acute anterior q-wave myocardial infarction: a study with serial multilea... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation Volume: 84 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1991 Jul |
Date Detail:
|
Created Date: 1991-08-05 Completed Date: 1991-08-05 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 160-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent African Continental Ancestry Group* Age Factors Child Coronary Disease / genetics European Continental Ancestry Group* Family Health* Female Follow-Up Studies Humans Lipoprotein(a) Lipoproteins / blood* Louisiana Male Myocardial Infarction* Prognosis Risk Factors Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
|
HL-38844/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Lipoprotein(a); 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peripheral tolerance induced in lymph nodes by syngeneic spleen cells inhibits generation of CTLs to...
Next Document: Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of a...