Document Detail


Racial analysis of the volume-renin relationship in human hypertension.
MedLine Citation:
PMID:  434969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 29 normotensive men (14 black, 15 white) and 36 hypertensive men (27 white, nine black) to examine the association of race with blood pressure, blood volume, and peripheral renin activity (pra). Blood volume was lower in white hypertensive men than in white normotensive men, but was similar in all blacks. When subjects were tested in the supine position, PRA was lower in black normotensive subjects than white normotensive subjects. The PRA did not differ among groups tested in an upright posture, while furosemide-stimulated PRA was lower in hypertensive than normotensive subjects of both races despite lower blood volumes in white hypertensive subjects. Differences of volume and renin measurements appear to reflect basic differences between whites and blacks with essential hypertension. We emphasize the need to consider race in the investigation of human hypertension.
Authors:
J A Mitas; R Holle; S B Levy; R A Stone
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  139     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Blood Pressure
Blood Volume*
Continental Population Groups*
European Continental Ancestry Group
Humans
Hypertension / blood,  epidemiology*,  physiopathology
Male
Posture
Renin / blood*
Time Factors
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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