| Racial differences in Parkinson's disease medication use in the reasons for geographic and racial differences in stroke cohort: a cross-sectional study. | |
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MedLine Citation:
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PMID: 19887838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies have suggested that African-American populations have a lower prevalence of Parkinson's disease (PD); however, because African-Americans are underrepresented in many cohorts, this relationship is poorly understood. We evaluated data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study to describe potential racial differences in PD prevalence. METHODS: We identified subjects using PD medications from the REGARDS study, a national longitudinal cohort study of 30,000 persons over age 45 with approximately equal representation of African-Americans and Whites. RESULTS: The prevalence of PD medication use across the cohort was 0.78% and was less among African-Americans (0.51%) than among Whites (0.97%; OR 1.90; 95% CI 1.31-2.74). There was an association of gender and PD medication use, with a prevalence of 0.61% in females and 0.97% in males (OR 1.57; 95% CI 1.13-2.18). There was no association with income, education level or geographic region of residence. CONCLUSIONS: The lower rate of PD medication use among African-Americans supports the suspected lower prevalence of PD among African-Americans suggested by other studies. While racial differences in PD diagnosis and treatment may contribute to the differences we observed, comparable disparities have not been observed in the REGARDS cohort for other diagnoses. Further studies of the REGARDS cohort may lead to important insights into potential biological differences in PD among African-Americans and Whites. |
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Authors:
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Talene A Yacoubian; George Howard; Brett Kissela; Charles D Sands; David G Standaert |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-11-04 |
Journal Detail:
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Title: Neuroepidemiology Volume: 33 ISSN: 1423-0208 ISO Abbreviation: Neuroepidemiology Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-09 Completed Date: 2010-01-28 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8218700 Medline TA: Neuroepidemiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 329-34 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. tyacoub@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Accidental Falls
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statistics & numerical data* African Americans / statistics & numerical data Age Factors Aged Aged, 80 and over Causality Cohort Studies Comorbidity Cross-Sectional Studies Drug Utilization European Continental Ancestry Group Female Humans Logistic Models Male Middle Aged Parkinson Disease / drug therapy*, ethnology* Prevalence Risk Factors Sex Distribution Southeastern United States / epidemiology Stroke / epidemiology* United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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U01 NS041588/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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