Document Detail


Racial differences in Parkinson's disease medication use in the reasons for geographic and racial differences in stroke cohort: a cross-sectional study.
MedLine Citation:
PMID:  19887838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have suggested that African-American populations have a lower prevalence of Parkinson's disease (PD); however, because African-Americans are underrepresented in many cohorts, this relationship is poorly understood. We evaluated data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study to describe potential racial differences in PD prevalence.
METHODS: We identified subjects using PD medications from the REGARDS study, a national longitudinal cohort study of 30,000 persons over age 45 with approximately equal representation of African-Americans and Whites.
RESULTS: The prevalence of PD medication use across the cohort was 0.78% and was less among African-Americans (0.51%) than among Whites (0.97%; OR 1.90; 95% CI 1.31-2.74). There was an association of gender and PD medication use, with a prevalence of 0.61% in females and 0.97% in males (OR 1.57; 95% CI 1.13-2.18). There was no association with income, education level or geographic region of residence.
CONCLUSIONS: The lower rate of PD medication use among African-Americans supports the suspected lower prevalence of PD among African-Americans suggested by other studies. While racial differences in PD diagnosis and treatment may contribute to the differences we observed, comparable disparities have not been observed in the REGARDS cohort for other diagnoses. Further studies of the REGARDS cohort may lead to important insights into potential biological differences in PD among African-Americans and Whites.
Authors:
Talene A Yacoubian; George Howard; Brett Kissela; Charles D Sands; David G Standaert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-04
Journal Detail:
Title:  Neuroepidemiology     Volume:  33     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-01-28     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. tyacoub@uab.edu
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MeSH Terms
Descriptor/Qualifier:
Accidental Falls / statistics & numerical data*
African Americans / statistics & numerical data
Age Factors
Aged
Aged, 80 and over
Causality
Cohort Studies
Comorbidity
Cross-Sectional Studies
Drug Utilization
European Continental Ancestry Group
Female
Humans
Logistic Models
Male
Middle Aged
Parkinson Disease / drug therapy*,  ethnology*
Prevalence
Risk Factors
Sex Distribution
Southeastern United States / epidemiology
Stroke / epidemiology*
United States / epidemiology
Grant Support
ID/Acronym/Agency:
U01 NS041588/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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