Document Detail


Racial differences in chronic immune stimulatory conditions and risk of non-Hodgkin's lymphoma in veterans from the United States.
MedLine Citation:
PMID:  21172877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine underlying etiologic factors that may explain the racial disparity in non-Hodgkin's lymphoma (NHL) incidence patterns.
PATIENTS AND METHODS: We assessed immune-related conditions and risk of developing NHL among more than 4 million hospitalized US veterans including 9,496 patients with NHL (7,999 white patients and 1,497 black patients) with up to 26 years of follow-up. We used time-dependent Poisson regression to estimate rate ratios (RRs) and 95% CIs for NHL risk among patients with a history of specific autoimmune diseases, infections, and allergies compared with patients without such history, adjusting for attained age, calendar year, race, number of hospital visits, and time between study entry and exit.
RESULTS: Patients with infectious conditions had an increased risk of developing NHL (RR, 1.2; 95% CI, 1.1 to 1.2), particularly for gastrohepatic, genital, and systemic infectious conditions. Patients with autoimmune disease were generally more likely to develop NHL than patients without autoimmune disease, especially for conditions that typically present with detectable autoantibodies with systemic involvement (RR, 2.0; 95% CI, 1.8 to 2.2). Allergies were also associated with increased risk (RR, 1.4; 95% CI, 1.3 to 1.5). Although the risk of NHL was lower for blacks than whites (RR, 0.87; 95% CI, 0.82 to 0.92), blacks had a slightly higher risk of NHL associated with infections than whites (likelihood ratio test, P = .002) and a tendency toward higher risk associated with allergies (likelihood ratio test, P = .05). Risks associated with autoimmune conditions were similar by race (likelihood ratio test, P = .5).
CONCLUSION: The observed difference in NHL risk by race supports a role for race-related differences in genes regulating immune/inflammatory response.
Authors:
Jill Koshiol; Tram Kim Lam; Gloria Gridley; David Check; Linda Morris Brown; Ola Landgren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2010-12-20
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  29     ISSN:  1527-7755     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-03-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  378-85     Citation Subset:  IM    
Affiliation:
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7248, USA. koshiolj@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
African Americans / statistics & numerical data*
Autoimmune Diseases / ethnology,  immunology
Chronic Disease
Communicable Diseases / ethnology,  immunology
European Continental Ancestry Group / statistics & numerical data*
Health Status Disparities*
Humans
Hypersensitivity / ethnology,  immunology
Immune System Diseases / ethnology*,  immunology
Incidence
Lymphoma, Non-Hodgkin / ethnology*,  immunology
Male
Middle Aged
Regression Analysis
Risk Assessment
Risk Factors
Time Factors
United States / epidemiology
Veterans / statistics & numerical data*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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