| Rachitic syndrome after disodium etidronate therapy in an adolescent. | |
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MedLine Citation:
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PMID: 8291954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 12-year-old patient with a severe traumatic brain injury developed heterotopic ossification (HO) with rapidly decreasing range of motion in multiple joints despite intensive passive range of motion exercises and the use of nonsteroidal antiinflammatory drugs (NSAIDs). His alkaline phosphatase was markedly elevated. Etidronate, 20mg/kg/d was used to control the ossification. After 7 months of continual etidronate use, the patient developed periarticular pain with widened growth plates, suggesting a rachitic syndrome. Serum laboratory panel including calcium, phosphorous, alkaline phosphatase, and vitamin D were normal. After 3 months off etidronate, radiological studies showed growth plate calcification, though not before development of bilateral slipped femoral capital epiphyses. Further improvement and resolution of all complications occurred 5 months after discontinuation of etidronate. Rachitic syndromes secondary to didronel use in a clinical setting has not been previously reported. Other possible causes for a rachitic syndromes were not present. Alternate treatments for children with or at risk for HO should be considered. |
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Authors:
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S L Silverman; E A Hurvitz; V S Nelson; A Chiodo |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 75 ISSN: 0003-9993 ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-02-22 Completed Date: 1994-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 118-20 Citation Subset: AIM; IM |
Affiliation:
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Department of Physical Medicine and Rehabilitation, University of Michigan Medical Center 48109. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Injuries
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complications Child Etidronic Acid / adverse effects*, therapeutic use Humans Male Ossification, Heterotopic / drug therapy, etiology Rickets / chemically induced* |
| Chemical | |
Reg. No./Substance:
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2809-21-4/Etidronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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