| Racemic resolution of RS-baclofen using lipase from Candida cylindracea. | |
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MedLine Citation:
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PMID: 15954592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Baclofen is chemically (RS)-beta-(aminomethyl)-4-chlorobenzene propanoic acid. It is used in therapy of pain and as a muscle relaxant. Baclofen produces analgesia by increasing the concentration of gamma amino butyric acid (GABA), the major rapid inhibitory transmitter. Both the isomers of baclofen have different therapeutic activity with respect to their interaction to the receptors at the site of action. Lipase from Candida cylindracea has been used as a catalyst for resolving racemic mixtures of numerous drug molecules. The present investigation deals with the racemic resolution of RS-baclofen using lipase from Candida cylindracea and a study of the factors affecting resolution. |
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Authors:
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R V Muralidhar; R R Chirumamilla; V N Ramachandran; R Marchant; P Nigam |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) Volume: 66 ISSN: 1373-7503 ISO Abbreviation: Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet Publication Date: 2001 |
Date Detail:
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Created Date: 2005-06-15 Completed Date: 2005-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100967625 Medline TA: Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet Country: Belgium |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Affiliation:
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School of Biomedical Sciences, University of Ulster at Coleraine, N. Ireland, United Kingdom, BT52 1SA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Baclofen
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chemistry*,
isolation & purification,
metabolism Candida / metabolism Catalysis Lipase / metabolism* Stereoisomerism Substrate Specificity gamma-Aminobutyric Acid |
| Chemical | |
Reg. No./Substance:
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1134-47-0/Baclofen; 56-12-2/gamma-Aminobutyric Acid; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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