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Racemic Resolution of some DL: -Amino Acids using Aspergillus fumigatus L: -Amino Acid Oxidase.
MedLine Citation:
PMID:  21590326     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The ability of Aspergillus fumigatus L: -amino acid oxidase (L: -aao) to cause the resolution of racemic mixtures of DL: -amino acids was investigated with DL: -alanine, DL: -phenylalanine, DL: -tyrosine, and DL: -aspartic acid. A chiral column, Crownpak CR+ was used for the analysis of the amino acids. The enzyme was able to cause the resolution of the three DL: -amino acids resulting in the production of optically pure D: -alanine (100% resolution), D: -phenylalanine (80.2%), and D: -tyrosine (84.1%), respectively. The optically pure D: -amino acids have many uses and thus can be exploited industrially. This is the first report of the use of A. fumigatus L: -amino acid oxidase for racemic resolution of DL: -amino acids.
Authors:
Susmita Singh; Binod K Gogoi; Rajib L Bezbaruah
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-18
Journal Detail:
Title:  Current microbiology     Volume:  -     ISSN:  1432-0991     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808448     Medline TA:  Curr Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biotechnology Division, North East Institute of Science and Technology, Council of Scientific and Industrial Research, Jorhat, 785006, Assam, India, susmitasingh123@gmail.com.
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