Document Detail

Race and physical activity: cardiovascular and renal response to sodium loading.
MedLine Citation:
PMID:  9086315     Owner:  NLM     Status:  MEDLINE    
Race and level of physical activity may be important factors affecting cardiovascular responsiveness to acute sodium intake. We examined the effects of a 4-day sodium loading procedure on heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure, 24-hour electrolyte excretion, and extracellular fluid volume (ECF) in African-American (n = 16) and Caucasian (n = 16) adult males. All subjects were normotensive with either moderately high (> or = 3 day/wk; > or = 20 min/day) or low (< or = 3 day/wk; < or = 20 min/day) physical activity levels. Subjects ingested either placebo or NaCl (0.2 g/kg/day) during two 4-day periods. Sodium loading increased SBP and decreased HR in all high physical activity subjects but not in low physical activity subjects (p < 0.05). Na+ excretion did not differ among groups, although urine volume and K+ excretion were lower, and Na+/K+ excretion ratio was higher in African-American compared to Caucasian subjects (p < 0.05). ECF, as measured by NaBr dilution, was greater in high physical activity subjects compared to low physical activity subjects (p < 0.05). These data suggest that high physical activity levels do not attenuate but rather exaggerate SBP response to a sodium load.
G D Thompson; V Bond; B S Cohen; R Tulley; D B West
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ethnicity & disease     Volume:  6     ISSN:  1049-510X     ISO Abbreviation:  Ethn Dis     Publication Date:  1996  
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9109034     Medline TA:  Ethn Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-65     Citation Subset:  IM    
Department of Health and Physical Education, University of Southwestern Louisiana, USA.
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MeSH Terms
African Continental Ancestry Group*
Cardiovascular Physiological Phenomena*
European Continental Ancestry Group*
Exercise / physiology*
Kidney / physiology*
Natriuresis / genetics,  physiology*
Physical Fitness / physiology
Sodium, Dietary / adverse effects*
Water-Electrolyte Balance / physiology
Grant Support
Reg. No./Substance:
0/Sodium, Dietary

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