Document Detail


Race, family history of hypertension, and sympathetic response to cold pressor testing.
MedLine Citation:
PMID:  9296307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This laboratory recently reported that the blood pressure and muscle sympathetic nerve activity (MSNA) responses to cold pressor testing are greater in normotensive blacks than in age- and weight-matched normotensive whites. The present study was designed to determine the relationship between race, family history of hypertension, and sympathetic response to cold pressor testing. The study used microneurography to measure MSNA responses to cold pressor testing in normotensive blacks with (n = 8) and without (n = 8) and normotensive white subjects with (n = 8) and without (n = 10) a positive family history of hypertension. Resting blood pressure was lower in black subjects without a positive family history of hypertension but otherwise resting blood pressure, heart rate, and MSNA were similar in the four groups. Black subjects with a family history of hypertension manifested a greater increase in blood pressure and MSNA than both white groups. Blood pressure and sympathetic responses of black subjects with a negative family history of hypertension tended to be intermediate and were not statistically different from the other three groups. These results indicate that the greater sympathetic response to cold stress observed in normotensive African-Americans is true only of black subjects with a positive family history of hypertension.
Authors:
D A Calhoun; M L Mutinga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood pressure     Volume:  6     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Affiliation:
Vascular Biology and Hypertension Program, University of Alabama at Birmingham, USA. card023@uabdpo.dpo.uab.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group*
Blood Pressure Determination
Body Weight
Cold Temperature
European Continental Ancestry Group*
Family Health
Humans
Hypertension / epidemiology,  genetics*,  physiopathology*
Infant, Newborn
Sympathetic Nervous System / physiopathology*
Grant Support
ID/Acronym/Agency:
K11 HL02568/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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