Document Detail


Race-ethnic variation in carotid bifurcation geometry.
MedLine Citation:
PMID:  19717017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Disturbances in local blood flow influenced by arterial geometry contribute to atherogenesis. Carotid bifurcation hemodynamics depend on the relative sizes of the common carotid artery (CCA), internal carotid artery (ICA), and external carotid artery (ECA), which vary considerably among individuals. The prevalence of carotid bifurcation atherosclerosis differs among race-ethnic groups and is generally lower in African Americans despite a more adverse vascular risk factor profile. We here examine whether there are race-ethnic differences in carotid bifurcation anatomy. METHODS: The diameters of the CCA, carotid bulb, ICA, and ECA were measured from consecutive cerebral angiograms of African American, white, and Caribbean Hispanic patients. The bulb/CCA, ICA/CCA, ECA/CCA, ECA/ICA, and total cross-sectional outflow/inflow ratio ([ICA(2) + ECA(2)]/CCA(2)) were calculated. RESULTS: The final analysis included 272 bifurcations of which 103 were among white, 87 Hispanic, and 82 African American patients. The mean age of the population was 59.8 +/- 15.8 years and 148 (54.4%) were men. African Americans had a lower ICA/CCA ratio (P < .001) and ICA/ECA ratio (P < .0001) and a higher ECA/CCA ratio (P < .0001) in comparison with the other two groups. CONCLUSION: We found significant differences in the relative sizes of the ICA, ECA, and CCA among race-ethnic groups. African Americans had a proportionally smaller ICA and larger ECA in comparison with whites and Caribbean Hispanics.
Authors:
Sebastian Koch; Donoffa Nelson; Tatjana Rundek; Jay Mandrekar; Alejandro Rabinstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  18     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Miami, Miller School of Medicine, Miami 33136, USA. skoch@med.miami.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans
Aged
Blood Flow Velocity / physiology
Brain / blood supply
Caribbean Region
Carotid Artery Diseases / epidemiology*,  ethnology*,  physiopathology
Carotid Artery, Common / pathology*,  physiopathology,  radiography
Carotid Artery, External / pathology*,  physiopathology,  radiography
Carotid Artery, Internal / pathology*,  physiopathology,  radiography
Cerebral Angiography
Cerebrovascular Circulation / physiology
Continental Population Groups
Ethnic Groups
European Continental Ancestry Group
Female
Hemodynamics
Hispanic Americans
Humans
Male
Middle Aged
Models, Cardiovascular
Pulsatile Flow
Risk Factors
Stroke / etiology,  physiopathology
Tunica Intima / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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