| Race-ethnic variation in carotid bifurcation geometry. | |
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MedLine Citation:
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PMID: 19717017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Disturbances in local blood flow influenced by arterial geometry contribute to atherogenesis. Carotid bifurcation hemodynamics depend on the relative sizes of the common carotid artery (CCA), internal carotid artery (ICA), and external carotid artery (ECA), which vary considerably among individuals. The prevalence of carotid bifurcation atherosclerosis differs among race-ethnic groups and is generally lower in African Americans despite a more adverse vascular risk factor profile. We here examine whether there are race-ethnic differences in carotid bifurcation anatomy. METHODS: The diameters of the CCA, carotid bulb, ICA, and ECA were measured from consecutive cerebral angiograms of African American, white, and Caribbean Hispanic patients. The bulb/CCA, ICA/CCA, ECA/CCA, ECA/ICA, and total cross-sectional outflow/inflow ratio ([ICA(2) + ECA(2)]/CCA(2)) were calculated. RESULTS: The final analysis included 272 bifurcations of which 103 were among white, 87 Hispanic, and 82 African American patients. The mean age of the population was 59.8 +/- 15.8 years and 148 (54.4%) were men. African Americans had a lower ICA/CCA ratio (P < .001) and ICA/ECA ratio (P < .0001) and a higher ECA/CCA ratio (P < .0001) in comparison with the other two groups. CONCLUSION: We found significant differences in the relative sizes of the ICA, ECA, and CCA among race-ethnic groups. African Americans had a proportionally smaller ICA and larger ECA in comparison with whites and Caribbean Hispanics. |
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Authors:
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Sebastian Koch; Donoffa Nelson; Tatjana Rundek; Jay Mandrekar; Alejandro Rabinstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Volume: 18 ISSN: 1532-8511 ISO Abbreviation: J Stroke Cerebrovasc Dis Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111633 Medline TA: J Stroke Cerebrovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 349-53 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Miami, Miller School of Medicine, Miami 33136, USA. skoch@med.miami.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Americans Aged Blood Flow Velocity / physiology Brain / blood supply Caribbean Region Carotid Artery Diseases / epidemiology*, ethnology*, physiopathology Carotid Artery, Common / pathology*, physiopathology, radiography Carotid Artery, External / pathology*, physiopathology, radiography Carotid Artery, Internal / pathology*, physiopathology, radiography Cerebral Angiography Cerebrovascular Circulation / physiology Continental Population Groups Ethnic Groups European Continental Ancestry Group Female Hemodynamics Hispanic Americans Humans Male Middle Aged Models, Cardiovascular Pulsatile Flow Risk Factors Stroke / etiology, physiopathology Tunica Intima / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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