Document Detail


Rabbit secretory components: identification of a third allotype, t63.
MedLine Citation:
PMID:  3624866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A third allotype of rabbit secretory component has been identified. The allotype previously referred to as t62 by our laboratory can now be subdivided into two allotypes, t62 and t63, with alloantisera capable of discriminating between the two. Results of family studies are consistent with a three allele system (t61, t62 and t63) at the t-locus. By SDS PAGE, electrophoretic mobilities of the multiple SC bands for each of the three allotypes are characteristic of the allotype; the apparent molecular sizes of the bands of the t62 allotype are 2 to 3 kDa lower than those for the t61 allotype. The banding patterns of the t61 and t63, although similar, are not identical to each other. Results of serologic cross-reaction studies and of tryptic peptide mapping studies suggest multiple structural differences between the allotypes as well as a closer relationship between t62 and t63 than between either of these allotypes and t61.
Authors:
W C Hanly; L Cook; M Kingzette; W Cox; S Frutiger; G J Hughes; J C Jaton
Related Documents :
23643856 - Food restriction-induced autophagy modulates degradation of mutant sod1 in an amyotroph...
16711536 - The risk of systemic reactions to skin prick-tests using food allergens: cicbaa data an...
8475146 - A positive response to an adverse reaction. diagnosis and management of food intoleranc...
18386436 - A case of severe allergy to pine-nut.
24885936 - Colorimetric detection of sulfite in foods by tmb-o2-co3o4 nanoparticles (nps) detectio...
2610616 - Plaque fluid ph, calcium and phosphorus responses to calcium food additives in a chewab...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  139     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-05     Completed Date:  1987-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1597-601     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Cross Reactions
Immunoglobulin A, Secretory / analysis
Immunoglobulin Allotypes / genetics*,  immunology
Immunoglobulin Fragments / genetics*
Isoantibodies / immunology
Molecular Weight
Peptide Mapping
Polymorphism, Genetic
Rabbits / genetics*,  immunology
Secretory Component / genetics*,  immunology
Grant Support
ID/Acronym/Agency:
GM-34533/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin A, Secretory; 0/Immunoglobulin Allotypes; 0/Immunoglobulin Fragments; 0/Isoantibodies; 0/Secretory Component

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.
Next Document:  Activation of human C1: analysis with Western blotting reveals slow self-activation.