Document Detail

Rabbit secretory components: identification of a third allotype, t63.
MedLine Citation:
PMID:  3624866     Owner:  NLM     Status:  MEDLINE    
A third allotype of rabbit secretory component has been identified. The allotype previously referred to as t62 by our laboratory can now be subdivided into two allotypes, t62 and t63, with alloantisera capable of discriminating between the two. Results of family studies are consistent with a three allele system (t61, t62 and t63) at the t-locus. By SDS PAGE, electrophoretic mobilities of the multiple SC bands for each of the three allotypes are characteristic of the allotype; the apparent molecular sizes of the bands of the t62 allotype are 2 to 3 kDa lower than those for the t61 allotype. The banding patterns of the t61 and t63, although similar, are not identical to each other. Results of serologic cross-reaction studies and of tryptic peptide mapping studies suggest multiple structural differences between the allotypes as well as a closer relationship between t62 and t63 than between either of these allotypes and t61.
W C Hanly; L Cook; M Kingzette; W Cox; S Frutiger; G J Hughes; J C Jaton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  139     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-05     Completed Date:  1987-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1597-601     Citation Subset:  AIM; IM    
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MeSH Terms
Cross Reactions
Immunoglobulin A, Secretory / analysis
Immunoglobulin Allotypes / genetics*,  immunology
Immunoglobulin Fragments / genetics*
Isoantibodies / immunology
Molecular Weight
Peptide Mapping
Polymorphism, Genetic
Rabbits / genetics*,  immunology
Secretory Component / genetics*,  immunology
Grant Support
Reg. No./Substance:
0/Immunoglobulin A, Secretory; 0/Immunoglobulin Allotypes; 0/Immunoglobulin Fragments; 0/Isoantibodies; 0/Secretory Component

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