| Rabbit endometrial relaxin: immunohistochemical localization during preimplantation, pregnancy, and lactation. | |
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MedLine Citation:
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PMID: 2346777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relaxin was localized in rabbit endometrium (but not ovary) on Days 4-30 of pregnancy and Days 2-5 of lactation. The hormone was not observed on Days 2 and 3 post coitus. Relaxin was found in endometrial glands throughout the length of the uterus on Days 4-9 post coitus. Later, on Days 11-23, relaxin was localized in both uterine endometrial gland cells and luminal epithelial cells. At this time, staining was observed only in the endometrium directly associated with implantation sites. Areas between implantation sites were devoid of staining. On Days 25-30 of pregnancy, relaxin was found mainly in uterine luminal epithelial cells. Few glands were observed with relaxin. During the first week of lactation, the staining profile was the same as that observed on Days 25-30. Relaxin was not found in the endometrium of pseudopregnant rabbits (Days 1, 4, 8, 12, and 16). The early appearance of uterine relaxin at the time the blastocyst migrates into the uterine cavity coupled with the hormone's later confinement to implantation sites suggests that the blastocyst initiates and the conceptus maintains uterine relaxin. |
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Authors:
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V H Lee; P A Fields |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of reproduction Volume: 42 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-07-11 Completed Date: 1990-07-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 737-45 Citation Subset: IM |
Affiliation:
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Department of Structural and Cellular Biology, University of South Alabama College of Medicine, Mobile 36688. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryonic Development / physiology* Endometrium / metabolism* Female Immunohistochemistry Lactation / metabolism* Pregnancy Pregnancy, Animal / metabolism* Rabbits Relaxin / analysis* Uterus / cytology |
| Grant Support | |
ID/Acronym/Agency:
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HD-15773/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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9002-69-1/Relaxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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