Document Detail


Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells.
MedLine Citation:
PMID:  20576682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rab10, a mammalian homolog of the yeast Sec4p protein, has previously been associated with endocytic recycling and biosynthetic membrane transport in cultured epithelia and with Glut4 translocation in adipocytes. Here, we report that Rab10 associates with primary cilia in renal epithelia in culture and in vivo. In addition, we find that Rab10 also colocalizes with exocyst proteins at the base of nascent cilia, and physically interacts with the exocyst complex, as detected with anti-Sec8 antibodies. These data suggest that membrane transport to the primary cilum may be mediated by interactions between Rab10 and an exocyst complex located at the cilium base.
Authors:
Clifford M Babbey; Robert L Bacallao; Kenneth W Dunn
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-24
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  299     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-09-24     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F495-506     Citation Subset:  IM    
Affiliation:
Department of Medicine, Indiana University Medical Center, Indianapolis, 46202, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Cilia / metabolism*
Dogs
Epithelial Cells / cytology,  metabolism
Kidney / cytology,  metabolism*
Membrane Transport Proteins / metabolism
Models, Animal
Vesicular Transport Proteins / metabolism*
rab GTP-Binding Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
R01 DK050141/DK/NIDDK NIH HHS; R01-DK-050141/DK/NIDDK NIH HHS; R01-DK-51098/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Membrane Transport Proteins; 0/Vesicular Transport Proteins; EC 3.6.1.-/rab GTP-Binding Proteins
Comments/Corrections

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