| Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. | |
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MedLine Citation:
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PMID: 20576682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rab10, a mammalian homolog of the yeast Sec4p protein, has previously been associated with endocytic recycling and biosynthetic membrane transport in cultured epithelia and with Glut4 translocation in adipocytes. Here, we report that Rab10 associates with primary cilia in renal epithelia in culture and in vivo. In addition, we find that Rab10 also colocalizes with exocyst proteins at the base of nascent cilia, and physically interacts with the exocyst complex, as detected with anti-Sec8 antibodies. These data suggest that membrane transport to the primary cilum may be mediated by interactions between Rab10 and an exocyst complex located at the cilium base. |
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Authors:
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Clifford M Babbey; Robert L Bacallao; Kenneth W Dunn |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-24 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 299 ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-09-24 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F495-506 Citation Subset: IM |
Affiliation:
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Department of Medicine, Indiana University Medical Center, Indianapolis, 46202, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Cilia / metabolism* Dogs Epithelial Cells / cytology, metabolism Kidney / cytology, metabolism* Membrane Transport Proteins / metabolism Models, Animal Vesicular Transport Proteins / metabolism* rab GTP-Binding Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK-050141/DK/NIDDK NIH HHS; R01-DK-51098/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Membrane Transport Proteins; 0/Vesicular Transport Proteins; EC 3.6.1.-/rab GTP-Binding Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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