Document Detail


RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.
MedLine Citation:
PMID:  22201794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with mutations in RUNX1. Located on chromosomal 21, the RUNX1 gene is involved in many forms of chromosomal translocations in leukemia. t(8;21) is one of the most common chromosomal translocations found in acute myeloid leukemia (AML), where it results in a fusion protein between RUNX1 and ETO. The RUNX1-ETO fusion protein is found in approximately 12% of all AML patients. In this review, we detail the structural features, functions, and models used to study both RUNX1 and RUNX1-ETO in hematopoiesis over the past two decades.
Authors:
Kentson Lam; Dong-Er Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  17     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2012  
Date Detail:
Created Date:  2011-12-28     Completed Date:  2012-04-03     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1120-39     Citation Subset:  IM    
Affiliation:
Moores Cancer Center, Department of Pathology and Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
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MeSH Terms
Descriptor/Qualifier:
Core Binding Factor Alpha 2 Subunit / chemistry,  physiology*
Hematopoiesis / physiology*
Humans
Leukemia / etiology*,  physiopathology
Neoplasms / genetics
Protein Conformation
Proto-Oncogene Proteins / physiology*
Transcription Factors / physiology*
Translocation, Genetic
Grant Support
ID/Acronym/Agency:
CA096735/CA/NCI NIH HHS; CA10450/CA/NCI NIH HHS; DK080665/DK/NIDDK NIH HHS; F30 HL103106/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Core Binding Factor Alpha 2 Subunit; 0/Proto-Oncogene Proteins; 0/RUNX1 protein, human; 0/RUNX1T1 protein, human; 0/Transcription Factors
Comments/Corrections

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