| RU 486 interferes with egg transport and retards the in vivo and in vitro development of mouse embryos. | |
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MedLine Citation:
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PMID: 2347197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oral administration of RU 486 at 100 mg/kg BW/day to mice on Days 1 and 2 of pregnancy caused retention of embryos in the oviduct and expulsion of those having entered the uterus. The treatment also retarded the development of embryos. In vitro study showed that RU 486 reduced the percentage of 2-cell mouse embryos developing into blastocysts. Thus, in addition to interfering with egg transport and impairing embryonic development in vivo, RU 486 can act directly on the embryo, interfering with preimplantation development in vitro. |
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Authors:
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Y Q Yang; J T Wu |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Contraception Volume: 41 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-07-11 Completed Date: 1990-07-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 551-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Massachusetts Medical Center, Worcester 01655. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Embryo Implantation / drug effects* Embryo, Mammalian / drug effects* Female Mice Mice, Inbred Strains Mifepristone / pharmacology* Ovulation / drug effects* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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HD 21322/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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