| RTD-1Mimic Containing γPNA Scaffold Exhibits Broad-Spectrum Antibacterial Activities. | |
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MedLine Citation:
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PMID: 22332599 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Macrocyclic peptides with multiple disulfide cross-linkages, such as those produced by plants and those found in nonhuman primates, as components of the innate immunity, hold great promise for molecular therapy because of their broad biological activities and high chemical, thermal, and enzymatic stability. However, for some, because of their intricate spatial arrangement and elaborate interstrand cross-linkages, they are difficult to prepare de novo in large quantities and high purity, due to the nonselective nature of disulfide-bond formation. We show that the disulfide bridges of RTD-1, a member of the θ-defensin subfamily, could be replaced with noncovalent Watson-Crick hydrogen bonds without significantly affecting its biological activities. The work provides a general strategy for engineering conformationally rigid, cyclic peptides without the need for disulfide-bond reinforcement. |
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Authors:
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Srinivas Rapireddy; Linda Nhon; Robert E Meehan; Jonathan Franks; Donna Beer Stolz; Dat Tran; Michael E Selsted; Danith H Ly |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-22 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry and Center for Nucleic Acids Science and Technology (CNAST), Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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