Document Detail


(RS), (R)(-) and (S)(+) derivatives of 2-N-arylalkylamino-1-butanol having antiarrhythmic properties.
MedLine Citation:
PMID:  3222179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of theophyllinyl-7'-ethyl derivatives of (RS), (R)(-) and (S)(+) 2-aminobutanol were synthesized and tested in various models of experimental arrhythmia for their preventive and curative properties; (R)(-) 2-N-theophyllinyl-7'-ethyl amino-1-butanol (1a) and (R)(-) theophyllinyl-7'-ethyl-2-N-methylamino-1-butanol (3a) hydrochlorides showed interesting antiarrhythmic properties. The levorotatory compounds of R configuration showed stronger protective and also therapeutic effect in different experimental arrhythmias.
Authors:
M Eckstein; J Zajaczkowska; L Samochowiec
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of pharmacology and pharmacy     Volume:  40     ISSN:  0301-0244     ISO Abbreviation:  Pol J Pharmacol Pharm     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1989-03-21     Completed Date:  1989-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366561     Medline TA:  Pol J Pharmacol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  401-11     Citation Subset:  IM    
Affiliation:
Department of Chemical Technology of Drugs, Copernicus Medical Academy, Kraków, Poland.
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MeSH Terms
Descriptor/Qualifier:
Amino Alcohols / chemical synthesis,  pharmacology*,  toxicity
Animals
Anti-Arrhythmia Agents*
Arrhythmias, Cardiac / drug therapy,  prevention & control
Drug Evaluation, Preclinical
Electrophysiology
Female
Guinea Pigs
Male
Papillary Muscles / drug effects,  physiology
Rabbits
Rats
Rats, Inbred Strains
Stereoisomerism
Structure-Activity Relationship
Theophylline / analogs & derivatives*,  chemical synthesis,  pharmacology,  toxicity
Chemical
Reg. No./Substance:
0/Amino Alcohols; 0/Anti-Arrhythmia Agents; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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