Document Detail

RPA and POT1: friends or foes at telomeres?
MedLine Citation:
PMID:  22373525     Owner:  NLM     Status:  MEDLINE    
Telomere maintenance in cycling cells relies on both DNA replication and capping by the protein complex shelterin. Two single-stranded DNA (ssDNA)-binding proteins, replication protein A (RPA) and protection of telomere 1 (POT1) play critical roles in DNA replication and telomere capping, respectively. While RPA binds to ssDNA in a non-sequence-specific manner, POT1 specifically recognizes singlestranded TTAGGG telomeric repeats. Loss of POT1 leads to aberrant accumulation of RPA at telomeres and activation of the ataxia telangiectasia and Rad3-related kinase (ATR)-mediated checkpoint response, suggesting that POT1 antagonizes RPA binding to telomeric ssDNA. The requirement for both POT1 and RPA in telomere maintenance and the antagonism between the two proteins raises the important question of how they function in concert on telomeric ssDNA. Two interesting models were proposed by recent studies to explain the regulation of POT1 and RPA at telomeres. Here, we discuss how these models help unravel the coordination, and also the antagonism, between POT1 and RPA during the cell cycle.
Rachel Litman Flynn; Sandy Chang; Lee Zou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-29     Completed Date:  2012-09-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  652-7     Citation Subset:  IM    
Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
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MeSH Terms
Cell Cycle / genetics,  physiology
Cell Cycle Proteins / genetics,  metabolism
Models, Biological
Protein-Serine-Threonine Kinases / genetics,  metabolism
Replication Protein A / genetics,  metabolism*
Telomere / genetics,  metabolism*
Telomere-Binding Proteins / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Cell Cycle Proteins; 0/POT1 protein, human; 0/Replication Protein A; 0/Telomere-Binding Proteins; EC 2.7.1.-/ATR protein, human; EC Kinases

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